PubMed · 8901346
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D F Moores. 1996. Under fire.. https://doi.org/10.1353/aad.2012.0035
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Dentinogenesis imperfecta (DGI) is characterized by discolored teeth with an opalescent sheen and dentin that fails to support enamel, causing it to easily chip. Two new studies show that DGI is associated with mutations in DSPP, a gene encoding dentin sialophosphoprotein that is processed into two proteins: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). These are key components of the dentin extracellular matrix (DECM). Notably, missense mutations in DSPP are also associated with progressive hearing loss.
Listening for intelligibility in disordered speech involves a complex interaction of factors, including listener experience. This study examines intelligibility as perceived by two groups (experienced and inexperienced listeners) in interpreting deaf speech. Speech samples were gathered from a hearing-impaired child over thirteen months, immediately post cochlear implantation. Results indicate that experienced listeners interpret more of disordered speech than inexperienced, but while experience appears to be a factor in intelligibility judgements, it does not alone guarantee higher intelligibility rating.