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PubMed · 8904221

[Structure and function of ClC chloride channels].

S Uchida
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Abstract

ClC chloride channels form a voltage-gated chloride channel family. It consists of at least 8 members of chloride channel, including the skeletal muscle-specific ClC-1 and the two very homologous kidney-specific chloride channels, ClC-K1 and ClC-K2. The dysfunction of ClC-1 is shown to lead to myotonia. Both ClC-K1 and ClC-K2 are involved in the transcellular chloride transport in the different nephron segments and may be involved in certain disorders of tubular function. This review focuses on (1) the structure and function of ClC chloride channels and (2) the involvement of ClC chloride channels in human diseases.

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AnimalsChloride ChannelsChloridesHumansKidneyKidney DiseasesMuscle, SkeletalMyotoniaEnglish AbstractJournal ArticleReview

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S Uchida. 1996. [Structure and function of ClC chloride channels].. https://pubmed.ncbi.nlm.nih.gov/8904221/

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