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Modulating platelet function with selective thrombin inhibitors.

M Verstraete
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Abstract

In addition to its pivotal role in blood coagulation, thrombin is one of the most important agonists for platelet recruitment and aggregation. Thrombin inhibitors impede thrombin-induced platelet aggregation but have no effect on aggregation induced by other agonists. A review is presented of selective thrombin inhibitors now in clinical investigation, some of which are also orally active.

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Administration, OralAdultAnimalsAntithrombinsArginineBlood PlateletsBoron CompoundsClinical Trials as TopicDogsDrug Evaluation, PreclinicalGlycineHirudin TherapyHirudinsHumansNaphthalenesOligopeptidesPeptide FragmentsPipecolic AcidsPiperidinesRecombinant ProteinsSulfonamidesThrombinJournal ArticleReview

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BibTeXRIS

M Verstraete. 1996. Modulating platelet function with selective thrombin inhibitors.. https://doi.org/10.1159/000217287

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