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PubMed · 9057380

Reactogenecity of indigenously produced measles vaccine.

I Bhargava·B C Chhaparwal·M A Phadke·S F Irani·B K Chakladhar·C P Maheshwari
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Abstract

OBJECTIVE: To assess the safety and reactogenecity of indigenously produced measles vaccine derived from EZ strain. DESIGN: A longitudinal clinical follow up after vaccination. SETTING: Hospital based and home follow up, as required. SUBJECTS: 12,470 children, 9 to 15 months old, immunized with measles vaccine of EZ strain, in accordance with the National Immunization Schedule, at five centers. METHODS: A clinical follow up of children at 1 day, 1 week, 2 weeks, 3 weeks and 6 weeks after measles vaccination. A detailed clinical neurological examination in children showing side effects. RESULTS: Mild side effects were documented in 31%. Of these, 90% were seen in the first two weeks, out of which two thirds were seen during the first week. Commonest side effects were coryza (10%), fever (9.8%), cough (3.2%) and diarrhea (3.2%). Convulsions, with no later sequelae were documented in 2 cases only. CONCLUSIONS: Measles vaccine manufactured in India, using EZ strain is a safe vaccine. It has a level of reactogenecity including neurological aspects, lower than that reported in India with the Schwarz strain vaccine.

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HumansIndiaInfantLongitudinal StudiesMeasles VaccineJournal Article

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I Bhargava, B C Chhaparwal, M A Phadke, S F Irani, B K Chakladhar, C P Maheshwari. 1996. Reactogenecity of indigenously produced measles vaccine.. https://pubmed.ncbi.nlm.nih.gov/9057380/

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