Uptake of 3H-testosterone in the skin of healthy women and in the skin of patients with acne vulgaris.

Abstract

Skin samples of interscapular region were taken from healthy women and patients with Acne vulgaris. The material was incubated with 3H-testosterone. The incubation of a part of the material was preceeded by an incubation with the unlabelled testosterone. An autoradiography was employed to detect and localize an uptake of 3H-testosterone in the skin. A significantly greater 3H-testosterone uptake was noted in the stratum basale and stratum spinosum of epidermis, sebaceous glands and hair sheaths and, in patients with Acne vulgaris, also within hair sacs and comedons.