PubMed · 9229693
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T Kudo, T Morishima, M Shibata. 1997-07-24. Hepatitis G infection.. https://doi.org/10.1056/nejm199707243370413
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RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in appropriate amounts, have correct termini, and can be translated efficiently. Many viruses with genomes of single-stranded positive-, negative-, and double-stranded RNA initiate RNA synthesis by a de novo (primer-independent) mechanism. This review summarizes biochemical features and variations of de novo initiation in viral RNA replication.