General class of multiparticulate dissolution models.

P V Pedersen; K F Brown

doi:10.1002/jps.2600661022

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General class of multiparticulate dissolution models.

P V Pedersen·K F Brown

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Abstract

The dissolution of multiparticulate systems under sink and nonsink conditions can be described rigorously according to a generally applicable formula on the basis of the single-particle dissolution model and the initial particle distribution. The kinetic model for log-normal systems dissolving under sink conditions is extended to nonsink conditions as a specific example. The equation presented describes a general class of multiparticulate models for various values of the dispersion parameter and the dissolution capacity coefficient.

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P V Pedersen, K F Brown. 1977. General class of multiparticulate dissolution models.. https://doi.org/10.1002/jps.2600661022

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