Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study.

G D'Haens; K Geboes; M Peeters; F Baert; N Ectors; P Rutgeerts

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PubMed · 9260788

Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study.

G D'Haens·K Geboes·M Peeters·F Baert·N Ectors·P Rutgeerts

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Abstract

OBJECTIVES: It is generally believed that the mucosal inflammation in ulcerative colitis is characterized by a diffuse, continuous involvement starting from the rectum without "skip areas." It was the aim of this study to examine 20 patients with established "left-sided ulcerative colitis" prospectively by ileocolonoscopy with biopsies to determine the extent and the continuity of the mucosal inflammation and the incidence of skip lesions in ulcerative colitis. METHODS: Twenty patients with left-sided ulcerative colitis underwent a complete ileocolonoscopy with biopsies of the terminal ileum and all colonic segments. The patients remained in clinical follow-up for at least 8 yr after the initial examination. RESULTS: The upper margin of inflammation was sharply demarcated in 6 patients and gradual in 14. Segmental inflammation, separated from the distal inflamed segment by apparently uninvolved mucosa, was found in 15 patients (75%) and always included the area around the appendiceal orifice. The correlation between endoscopic abnormalities and histological changes was excellent. CONCLUSION: In so-called "left-sided" ulcerative colitis distal involvement may be accompanied by more proximal areas of inflammation, particularly in the periappendiceal area of the cecum.

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G D'Haens, K Geboes, M Peeters, F Baert, N Ectors, P Rutgeerts. 1997. Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study.. https://pubmed.ncbi.nlm.nih.gov/9260788/

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