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PubMed · 9303825

[Injectable phenytoin: problems of stability in solution].

A Francés·A García Martí·M Bruck
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Abstract

Because of its efficient antiseizure activity, intravenous phenytoin remains a major agent in acute therapy, although it is associated with many pharmacokinetical and toxicological problems. This contribution focuses on the difficulties in finding the appropriate mode of intravenous administration, a matter which is of considerable clinical importance. The fact that precipitations of phenytoin occur when the product is incorrectly diluted is common knowledge--yet the pharmacy department is frequently contacted because of an improper handling of the products available. A review of the factors contributing to precipitation problems, the i.v. products in use in the Grand-Duchy of Luxembourg and the possible i.v. dilutions for these products are discussed.

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Chemical PrecipitationDrug StabilityHumansInjections, IntravenousPhenytoinSolubilityEnglish AbstractJournal Article

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A Francés, A García Martí, M Bruck. 1997. [Injectable phenytoin: problems of stability in solution].. https://pubmed.ncbi.nlm.nih.gov/9303825/

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