PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 9313052

[Prostatic malacoplakia. Clinical case].

J A Virseda Rodríguez·J Martín de Francisco·M Morente González·I Hernández Millán·M Segura Martín
View original source ↗Export metadata ↓

Abstract

OBJECTIVE: A case of malakoplakia of the prostate is described. This uncommon localization and the problems encountered in making the histopathological differential diagnosis prompted us to report the present case. METHODS/RESULTS: Adenocarcinoma of the prostate was suspected. The patient was submitted to TURP. Histopathological analysis of the specimen disclosed malakoplakia of the prostate. CONCLUSION: The diagnosis of malakoplakia of the prostate is essentially histopathological and depends on the ability of the pathologist to identify the typical inclusion bodies described by Michaelis and Gutmann.

Explore related subjects

AdenocarcinomaAgedDiagnosis, DifferentialHumansInclusion BodiesMalacoplakiaMaleProstatic DiseasesProstatic NeoplasmsCase ReportsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J A Virseda Rodríguez, J Martín de Francisco, M Morente González, I Hernández Millán, M Segura Martín. 1997. [Prostatic malacoplakia. Clinical case].. https://pubmed.ncbi.nlm.nih.gov/9313052/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2001

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung.

Defects in the repair and maintenance of DNA increase risk for cancer. X-ray cross-complementing group 1 protein (XRCC1) is involved with the repair of DNA single-strand breaks. A nucleotide substitution of guanine to adenine leading to a non-conservative amino acid change was identified in the XRCC1 gene at codon 399 (Arg/Gln). This change is associated with higher levels of aflatoxin B1-adducts and glycophorin A somatic mutations. A case-control study was conducted to test the hypothesis that the 399Gln allele is positively associated with risk for adenocarcinoma of the lung. XRCC1 genotypes were assessed at codon 399 in 172 cases of lung adenocarcinoma and 143 cancer-free controls. Two ethnic populations were represented, non-Hispanic White and Hispanic. The distribution of XRCC1 genotypes differed between cases and controls. Among cases, 47.7% were Arg/Arg, 35.5% were Arg/Gln, and 16.9% were Gln/Gln. Among controls, XRCC1 allele frequencies were 45.5% for Arg/Arg, 44.8% for Arg/Gln, and 9.8% for Gln/Gln. Logistic regression analysis was used to assess the association between lung adenocarcinoma and the G/G genotype relative to the A/A or A/G genotypes. In non-Hispanic White participants, the lung cancer risk associated with the G/G genotype increased significantly after adjustment for age (OR=2.81; 95% CI, 1.2-7.9; P=0.03) and increased further after adjustment for smoking (OR=3.25; 95% CI, 1.2-10.7; P=0.03). Among all groups, a significant association was found between the G/G homozygote and lung cancer (OR=2.45; 95% CI, 1.1-5.8; P=0.03) after adjustment for age, ethnicity, and smoking. This study links a functional polymorphism in the critical repair gene XRCC1 to risk for adenocarcinoma of the lung.

Adenocarcinoma↗
PubMed2001

Lung cancer in lifetime nonsmoking men - results of a case-control study in Germany.

Epidemiological studies of lung cancer among nonsmoking men are few. This case-control study was conducted among lifetime nonsmoking men between 1990 and 1996 in Germany to examine lung cancer risk in relation to occupation, environmental tobacco smoke, residential radon, family history of cancer and previous lung disease. A total of 58 male cases with confirmed primary lung cancer and 803 male population controls who had never smoked more than 400 cigarettes in their lifetime were personally interviewed by a standardized questionnaire. In addition, 1-year radon measurements in the living and bedroom of the subjects' last dwelling were carried out. Unconditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Having ever worked in a job with known lung carcinogens was associated with a two-fold significantly increased lung cancer risk (OR = 2.2; CI = 1.0-5.0), adjusted for age and region. The linear trend test for lung-cancer risk associated with radon exposure was close to statistical significance, demonstrating an excess relative risk for an increase in exposure of 100 Bq m(-3)of 0.43 (P = 0.052). Nonsignificantly elevated effects of exposure to environmental tobacco smoke in public transportation and in social settings were observed. No associations with a family history of cancer or previous lung diseases were found. Our results indicate that occupational carcinogens and indoor radon may play a role in some lung cancers in nonsmoking men.

Adenocarcinoma↗