Aging, neuroendocrine function, and osteoporosis.

M Peterlik

doi:10.1016/s0531-5565(96)00160-x

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Aging, neuroendocrine function, and osteoporosis.

M Peterlik

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Abstract

Osteoporosis may occur in both women and men. Osteoporosis is defined as age-related involutional bone loss that exceeds that observed in the normal population of the same age and sex. The hallmark of the disease is a reduction in mineralized bone matrix. Osteoporosis is a multifactorial disease and can be considered the result of impaired coordination of bone remodeling ("resorption/formation coupling"). This review describes the role of systemic hormones and local acting mediators, including neuropeptides and neurotransmitters, in the control of bone turnover. Furthermore the significance of age-related (neuro)endocrine dysfunction for bone remodeling and consequently for development of osteoporosis is discussed.

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Aging Animals Bone Remodeling Endocrine System Diseases Humans Neurosecretory Systems Osteoporosis Journal Article Research Support, Non-U.S. Gov't Review

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M Peterlik. Aging, neuroendocrine function, and osteoporosis.. https://doi.org/10.1016/s0531-5565(96)00160-x

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