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G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia.

L T Vlasveld·M de Haas·A A Ermens·L Porcelijn·J A van Marion-Kievit·A E von dem Borne
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Abstract

We present a case of an 81-year-old man with secondary autoimmune granulocytopenia in association with autoimmune thrombocytopenia. Treatment with granulocyte colony-stimulating factor (G-CSF) (5 micrograms/ kg/day s.c.) resulted in a rapid increase in the number of circulating granulocytes with a pronounced left shift. These changes were accompanied by up-regulation of the surface expression of Fc gamma RI (CD64) and Fc gamma RII (CD32) on the granulocytes. In addition, we noted a strong up-regulation of the Fc gamma RIII (CD16) and the activation markers CD11b and CD66b on the granulocytes. The increase in the number of circulating granulocytes was followed by a dramatic decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies. It is hypothezised that the decrease in the level of cell-bound as well as circulating anti-granulocyte antibodies may be the result of an increased adsorption of the antibodies by the granulocytes.

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AgedAged, 80 and overAgranulocytosisAutoantibodiesAutoimmune DiseasesGranulocyte Colony-Stimulating FactorGranulocytesHumansMaleReceptors, IgGThrombocytopeniaUp-RegulationCase ReportsJournal Article

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L T Vlasveld, M de Haas, A A Ermens, L Porcelijn, J A van Marion-Kievit, A E von dem Borne. G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia.. https://doi.org/10.1007/s002770050313

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