The renal dopamine system.

A Aperia; A C Eklöf; U Holtbäck; S Nowicki; M Sundelöf; P Greengard

doi:10.1016/s1054-3589(08)60885-6

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The renal dopamine system.

A Aperia·A C Eklöf·U Holtbäck·S Nowicki·M Sundelöf·P Greengard

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Abstract

Intrarenally formed dopamine induced natriuresis by inhibiting the activity of renal tubular Na/KATPase. This effect is mediated via a complex signal network, which includes inhibition of PP1 via the adenylyl cyclase-PKA-DARPP32 pathway and activation of PKC via the PLA2-arachidonic acid-20HETE pathway. The renal dopamine availability is a major determinant of the natriuretic effect of dopamine and is to a large extent modulated by the activity of COMT. The possibility that regulation of dopamine storage and release influences renal dopamine effects should be considered.

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Adenylyl Cyclases Animals Arachidonic Acid Catechol O-Methyltransferase Cyclic AMP-Dependent Protein Kinases Dopamine Dopamine and cAMP-Regulated Phosphoprotein 32 Hydroxyeicosatetraenoic Acids Kidney Kidney Tubules Natriuresis Nerve Tissue Proteins Phospholipases A Phospholipases A2 Phosphoproteins Signal Transduction Sodium-Potassium-Exchanging ATPase Journal Article

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A Aperia, A C Eklöf, U Holtbäck, S Nowicki, M Sundelöf, P Greengard. 1998. The renal dopamine system.. https://doi.org/10.1016/s1054-3589(08)60885-6

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