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PubMed · 933411

Physostigmine--its use and abuse.

W E Walker·R C Levy·I B Hanenson
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Abstract

Physostigmine salicylate, a cholinesterase inhibitor, has been shown to reverse the effects of certain drugs with anticholinergic properties. The paper provides a brief historical account of physostigmine, reviews the cholinergic drugs and their effects and suggests a management protocol based on physiologic criteria. Twenty-six overdose cases, recently treated with physostigmine, are summarized. The controversy regarding the etiology of seizures following physostigmine administration is discussed.

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Cholinesterase InhibitorsDose-Response Relationship, DrugHumansPhysostigminePoisoningSubstance-Related DisordersJournal Article

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W E Walker, R C Levy, I B Hanenson. 1976. Physostigmine--its use and abuse.. https://doi.org/10.1016/s0361-1124(76)80253-5

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