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Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.

S A Anderson·D D Eisenstat·L Shi·J L Rubenstein
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Abstract

Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.

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AnimalsCalbindinsCell MovementCorpus StriatumCulture TechniquesCytoskeletal ProteinsDNA-Binding ProteinsGenes, HomeoboxGlutamate DecarboxylaseHomeodomain ProteinsInterneuronsMiceMutationNeocortexRNA-Binding ProteinsS100 Calcium Binding Protein GTelencephalonTranscription Factorsgamma-Aminobutyric AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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S A Anderson, D D Eisenstat, L Shi, J L Rubenstein. 1997-10-17. Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.. https://doi.org/10.1126/science.278.5337.474

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