5-Hydroxytryptamine extraction by the lung.

L H Cronau; M D Kerstein; S Mandel; C N Gillis

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PubMed · 936048

5-Hydroxytryptamine extraction by the lung.

L H Cronau·M D Kerstein·S Mandel·C N Gillis

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Abstract

Both 5-hydroxytryptamine and norepinephrine are removed from blood during a single passage through the pulmonary vasculature of the dog; 5-hydroxytryptamine is removed to a greater degree than is norepinephrine. The magnitude of extraction of both 5-hydroxytryptamine and norepinephrine is similar to that previously determined in man. In the intact dog, imipramine inhibits the uptake of 5-hydroxytryptamine by the lung in a dose-dependent manner.

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Animals Carbon Radioisotopes Dogs Dose-Response Relationship, Drug Imipramine Lung Norepinephrine Serotonin Tritium Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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L H Cronau, M D Kerstein, S Mandel, C N Gillis. 1976. 5-Hydroxytryptamine extraction by the lung.. https://pubmed.ncbi.nlm.nih.gov/936048/

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