PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 9361396

Progestins and bone.

J H Thijssen
View original source ↗Export metadata ↓

Abstract

Since the introduction of hormone replacement therapy which combines administration of oestrogens with cyclic or continuous administration of progestins, attention has been paid to the possible modulating effect of the progestin on the beneficial effects of the oestrogens. In this review data regarding the effects of progestins and of oestrogen/progestin combinations on bone in women have been summarized. The conclusion is that there is no evidence for a negative influence of progestins on the beneficial effects of oestrogens on the bone. To the contrary, progestins seem to have additional bone sparing properties because they are capable of stimulating the formation of bone, but the exact mechanism is still under discussion.

Explore related subjects

Bone DensityClimactericDrug Therapy, CombinationEstrogen Replacement TherapyFemaleHumansProgesterone CongenersJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J H Thijssen. 1997. Progestins and bone.. https://pubmed.ncbi.nlm.nih.gov/9361396/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2024

Is there a causal relationship between resistin levels and bone mineral density, fracture occurrence? A mendelian randomization study.

BACKGROUND: In a great many of observational studies, whether there is a relevance of resistin levels on bone mineral density (BMD) and fracture occurrence has been inconsistently reported, and the causality is unclear. METHODS: We aim to assess the resistin levels on BMD and fracture occurrence within a Mendelian randomization (MR) analysis. Exposure and outcome data were derived from the Integrative Epidemiology Unit (IEU) Open genome wide association studies (GWAS) database. Screening of instrumental variables (IVs) was performed subject to conditions of relevance, exclusivity, and independence. Inverse variance weighting (IVW) was our primary method for MR analysis based on harmonized data. Weighted median and MR-Egger were chosen to evaluate the robustness of the results of IVW. Simultaneously, heterogeneity and horizontal pleiotropy were also assessed and the direction of potential causality was detected by MR Steiger. Multivariable MR (MVMR) analysis was used to identify whether confounding factors affected the reliability of the results. RESULTS: After Bonferroni correction, the results showed a suggestively positive causality between resistin levels and total body BMD (TB-BMD) in European populations over the age of 60 [β(95%CI): 0.093(0.021, 0.165), P = 0.011]. The weighted median [β(95%CI): 0.111(0.067, 0.213), P = 0.035] and MR-Egger [β(95%CI): 0.162(0.025, 0.2983), P = 0.040] results demonstrate the robustness of the IVW results. No presence of pleiotropy or heterogeneity was detected between them. MR Steiger supports the causal inference result and MVMR suggests its direct effect. CONCLUSIONS: In European population older than 60 years, genetically predicted higher levels of resistin were associated with higher TB-BMD. A significant causality between resistin levels on BMD at different sites, fracture in certain parts of the body, and BMD in four different age groups between 0-60 years of age was not found in our study.

Bone Density↗