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PubMed · 9407304

New anionic polyelectrolyte hydrogel for corneal surgery.

J Honiger·C Couturier·P Goldschmidt·F Maillet·M D Kazatchkine·L Laroche
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Abstract

A new high-water-content (78%) anionic polyelectrolyte hydrogel was obtained by phase inversion (demixion) of a polymer solution containing 9.0% poly(acrylonitrile sodium methallylsulphonate), 85.0% dimethylformamide, and 6.0% saline solution (0.9% NaCl). The hydrogel is permeable to water, saline, urea, creatinine, glucose, human albumin, and saline-dissolved oxygen. Investigation of the interactions between human serum and surfaces prepared with the new yielded hydrogel, compared to serum interaction with silica-free silicone (RTV), regenerated cellulose (Cuprophan), MMA/PVP copolymer (Lidofilcon), PMMA (Perspex), FIFE (Gore-Tex), and poly(acrylonitrile sodium methallylsulphonate) hemodialysis membrane (AN-69), showed the hydrogel and hemodialysis membrane (both prepared with AN-69 copolymer) to be the only materials devoid of complement (C')-activating ability.

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Biocompatible MaterialsComplement ActivationCorneaElectrolytesGelsHumansIn Vitro TechniquesKidneys, ArtificialMaterials TestingMembranes, ArtificialOxygenPermeabilityPolyelectrolytesPolymersRefractometryStress, MechanicalWaterComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

J Honiger, C Couturier, P Goldschmidt, F Maillet, M D Kazatchkine, L Laroche. 1997-12-15. New anionic polyelectrolyte hydrogel for corneal surgery.. https://doi.org/10.1002/(sici)1097-4636(19971215)37%3A4%3C548%3A%3Aaid-jbm14%3E3.0.co%3B2-4

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