[Structural-functional UV-modifications of C1q factor of the human complement system].

V V Gusinskaia; V G Artiukhov; K P Sergeev

PubMed · 9467649

[Structural-functional UV-modifications of C1q factor of the human complement system].

V V Gusinskaia·V G Artiukhov·K P Sergeev

Abstract

The structural transformations of C1q-protein induced by the UV-light at doses 151 and 2265 J/m2 has been determined by means of acid-basic titration, IR- ans UV-spectrophotometry. These transformations are stipulated by unfolding of its molecules without change of the secondary structure types ratio and accompanies by exposition on aromatic amino acid residues as well as glutamine and asparagine acids, lysine, hydroxylysine and cysteine on the globule surface. The correlation between structural photomodifications and processes of functional activation of C1q has been established.

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Amino Acids Asparagine Complement C1q Cysteine Glutamine Humans Hydroxylysine Lysine Models, Immunological Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Ultraviolet Rays Comparative Study English Abstract Journal Article

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V V Gusinskaia, V G Artiukhov, K P Sergeev. [Structural-functional UV-modifications of C1q factor of the human complement system].. https://pubmed.ncbi.nlm.nih.gov/9467649/

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