Methamphetamine self-administration in the cat.

R L Balster; M M Kilbey; E H Ellinwood

doi:10.1007/bf00421107

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PubMed · 951458

Methamphetamine self-administration in the cat.

R L Balster·M M Kilbey·E H Ellinwood

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Abstract

A procedure for studing intravenous drug self-administration in the cat is described. Ten cats were given 24-h access to methamphetamine reinforcement (0.04 mg/kg/inj). The subjects maintained a significantly higher response rate for drug reinforcement than for saline. The pattern of self-administration over days alternated between periods of high and low drug intake. Six additional cats were used to study the effect of dose per injection on methamphetamine self-administration under conditions of limited access. When methamphetamine was subtituted at various doses per infusion in animals maintained on cocaine reinforcement, response rate was shown to be an inverted U-shaped function of dose. These studies demonstrate that methamphetamine is a reinforcer in the cat and its patterns of intake under conditions of 24-h and limited access resemble other species.

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Animals Cats Cocaine Female Infusions, Parenteral Methamphetamine Psychopharmacology Reinforcement, Psychology Self Stimulation Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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R L Balster, M M Kilbey, E H Ellinwood. 1976-04-15. Methamphetamine self-administration in the cat.. https://doi.org/10.1007/bf00421107

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