Lessons from TGF-beta transgenic mice.

E P Böttinger; J B Kopp

doi:10.1159/000057364

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Lessons from TGF-beta transgenic mice.

E P Böttinger·J B Kopp

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Abstract

Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.

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Animals Disease Gene Expression Humans Mice Mice, Transgenic Mutagenesis Receptors, Transforming Growth Factor beta Signal Transduction Transforming Growth Factor beta Journal Article Review

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E P Böttinger, J B Kopp. 1998. Lessons from TGF-beta transgenic mice.. https://doi.org/10.1159/000057364

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