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PubMed · 9548847

Antibacterial steroidal alkaloids from Sarcococca saligna.

A Rahman·S Anjum·A Farooq·M R Khan·Z Parveen·M I Choudhary
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Abstract

Two new pregnane-type steroidal alkaloids, saligcinnamide [(20S,2'E)-20-(N,N-dimethylamino)-3beta-(3'-phenyl-2'-propenyl-N-meth ylamido)pregnane](1) and N(a)-methyl epipachysamine-D [(20S)-20-(N,N-dimethylamino)-3beta-(N-methylbenzamido)pregnane](2 ), along with a known base, epipachysamine D [(20S)-20-(N,N-dimethylamino)-3beta-(benzamido)pregnane] (3), were isolated from the EtOH extracts of the roots and stems of Sarcococca saligna. The new bases exhibited antibacterial activity against several human pathogenic bacteria. Two derivatives of 1, dihydrosaligcinnarnide [(20S)-20-(N,N-dimethylamino)-3beta-(3'-phenylpropionoyl-N-meth ylamido)pregnane](4) and dihydrosaligcinnamine [(20S)-20-(N,N-dimethylamino)-3beta-N-(3'-phenylpropyl-N-methylamino)pre gnane](5), and a derivative of 2, N(a)-methyl epipachysamine [(20S)-20-(N,N-dimethylamino)-3beta-(N-benzyl,N-methylamino)pregnane](6) were prepared and their antibacterial activity determined.

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AlkaloidsAnti-Bacterial AgentsBacteriaMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsMolecular ConformationPakistanPlants, MedicinalSpectrometry, Mass, Fast Atom BombardmentSpectrophotometry, UltravioletJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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BibTeXRIS

A Rahman, S Anjum, A Farooq, M R Khan, Z Parveen, M I Choudhary. 1998. Antibacterial steroidal alkaloids from Sarcococca saligna.. https://doi.org/10.1021/np970294a

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