PubMed · 9560690
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G McCoy. 1997. Occlusion and implants.. https://pubmed.ncbi.nlm.nih.gov/9560690/
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Plasminogen activator (PA) converts plasminogen to plasmin, and plasmin activates the kinin cascade and latent extracellular matrix metalloproteases. The periodontal ligament serves to anchor the tooth to the alveolus and functions as a cushion between these hard tissues to migrate occlusal force during mastication. We reported previously that repeated mechanical tension force (MTF) as an experimental model of a traumatic occlusion, increased PA activity in human periodontal ligament derived fibroblast (hPLF) cells. In this study, the influence of in vitro cellular aging on MTF-stimulated PA activity in hPLF cells was studied. Aged hPLF cells produced a significantly higher PA activity when compared with those of young hPLF cells in response to MTF in a time- and magnitude-dependent manner. tPA mRNA levels in aged cells were higher than those in young cells, whereas PAI-1 mRNA remained unchanged and uPA mRNA was not detected. Because MTF-stimulated PA activity from hPLF cells was increased by in vitro cellular aging, aging of the periodontal ligament may affect the severity of the inflammation and the degradation of the extracellular matrix of periodontal ligament tissue by producing a large amount of PA in response to excessive force such as a traumatic occlusion.
Receptors inside human incisors appear to respond to stress (comparable to pressure as opposed to force) on the crown. This ability may be used to limit the stress applied to teeth or to discriminate between the hardness of objects clenched between upper and lower teeth. Here the hypothesis that these receptors are activated by fluid squeezed out of dentinal tubules when the loaded tooth is stressed was tested. Vertically compressing the crowns of extracted human teeth with loads of from 20 to 120 N, similar to those used in other studies and during natural chewing, did indeed displace fluid into the pulp. The fluid was displaced away from the crown immediately after the tooth had been loaded and moved back into the crown when the load was removed. The volume ranged from 3.5 to 22.2x10(3) pl, similar to that known to stimulate single pulpal nerve fibres. Thus, normal chewing forces could displace sufficient fluid out of dentine to excite putative mechanoreceptors somewhere inside the dentine/pulp complex.
The loss of one or more teeth is normally treated with conventional fixed or removable partial dentures or with implant supported fixed or removable dentures. This study investigated stresses formed around the implant and the antagonist natural tooth under occlusal force in the substitution of a missing lower first molar with a rigid or resilient IMZ (Intra Mobil Zylinder) implant, using the finite element stress analysis method. The results indicate that a bite force of 143 N resulted in high compressive stresses around the roots of a natural tooth opposing a restoration supported by an IMZ implant with rigid type abutment. It is speculated that these high compressive stresses may contribute to intrusion of the tooth.