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PubMed · 9604166

Activity and passive-avoidance learning in cobalt-injected rats.

M Czarnota·D Whitman·R Berman
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Abstract

A wide range of cognitive-behavioral sequelae, including memory deficits, results from hard metal disease in humans. Cobalt is a common component in the manufacture of hard metals and is a biologically active, toxic substance. This study examined the effects of cobalt exposure in rats. Results showed decreased exploratory behavior and a trend for higher-dose subjects to show decreased passive avoidance learning. No significant differences in active maze learning were found. These results indicate the value of further explorations of the cognitive-behavioral effects of cobalt exposure and suggest a number of methodological cautions.

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AnimalsAvoidance LearningCobaltDose-Response Relationship, DrugExploratory BehaviorInjections, IntraperitonealMaleMaze LearningMemoryRatsRats, Inbred StrainsReaction TimeJournal Article

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M Czarnota, D Whitman, R Berman. 1998. Activity and passive-avoidance learning in cobalt-injected rats.. https://doi.org/10.3109/00207459808986409

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