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Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus.

R Reifen·M Blank·A Afek·Y Kopilowiz·D Sklan·M E Gershwin·B German·S Yoshida·Y Shoenfeld
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Abstract

OBJECTIVE: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE). METHODS: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out. RESULTS: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil. CONCLUSION: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.

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AnimalsAntibodies, Anti-IdiotypicAntibodies, AnticardiolipinAntibodies, AntinuclearBody WeightDNADietary Fats, UnsaturatedDisease Models, AnimalFatty Acids, UnsaturatedFemaleLinseed OilLupus Erythematosus, SystemicMiceMice, Inbred BALB CMineralsJournal ArticleResearch Support, Non-U.S. Gov't

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R Reifen, M Blank, A Afek, Y Kopilowiz, D Sklan, M E Gershwin, B German, S Yoshida, Y Shoenfeld. 1998. Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus.. https://doi.org/10.1191/096120398678919985

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