Immunodeficiency, xanthomas and obstructive liver disease.

J N Isenberg; R F Hanson; G C Williams; J Zavoral; A R Page; H L Sharp

doi:10.1016/0002-9343(76)90377-6

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PubMed · 961702

Immunodeficiency, xanthomas and obstructive liver disease.

J N Isenberg·R F Hanson·G C Williams·J Zavoral·A R Page·H L Sharp

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Abstract

Chronic obstructive liver disease and secondary hyperlipidemia developed in an immunodeficient boy. Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restoration of normal serum concentrations of lipids and bile acids. This improvement may result from shifting the bile acid pool from the peripheral blood compartment to the enterohepatic circulation.

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Bile Acids and Salts Chenodeoxycholic Acid Child Cholestyramine Resin Cholic Acids Humans Hypercholesterolemia Hyperlipidemias Immunologic Deficiency Syndromes Liver Diseases Male Phenobarbital Pruritus Xanthomatosis Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

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J N Isenberg, R F Hanson, G C Williams, J Zavoral, A R Page, H L Sharp. 1976. Immunodeficiency, xanthomas and obstructive liver disease.. https://doi.org/10.1016/0002-9343(76)90377-6

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