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Aqueous ascorbate concentration in hereditary buphthalmic rabbits.

K W Lam·P Lee·R Fox
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Abstract

Some aqueous humor constituents, including ascorbate, protein, and sodium, potassium, and calcium ions, were analyzed in three groups of adult buphthalmic (bu/bu) rabbits from strain AXBU/J and in control rabbits of the closely related strain AX/J. Aqueous humor ascorbate concentration of the normal strain was 22.5/"2.3mg/100ml. The buphthalmic rabbits that had no meaningful clinical signs of glaucoma at the time of sample collection had lower values (11.7/"1.7mg/100ml). Much lower values were observed in the bu/bu mutant rabbits that showed mild to severe glaucoma: 8.9/"3.8mg/100 ml and 1.9"/0.4mg/100ml, respectively. It was concluded that reduction of aqueous ascorbate is a biochemical change associated with the pathological development of buphthalmia in rabbits of the AXBU/J strain. However, the exact mechanism is still unclear.

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AnimalsAqueous HumorAscorbic AcidCalciumDisease Models, AnimalEye ProteinsGenotypeGlaucomaHydrophthalmosIntraocular PressurePotassiumRabbitsSodiumJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K W Lam, P Lee, R Fox. 1976. Aqueous ascorbate concentration in hereditary buphthalmic rabbits.. https://doi.org/10.1001/archopht.1976.03910040395015

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