Mobile elements and disease.

H H Kazazian

doi:10.1016/s0959-437x(98)80092-0

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PubMed · 9690999

Mobile elements and disease.

H H Kazazian

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Abstract

A substantial fraction of mammalian genomes is composed of mobile elements and their remnants. Recent insertions of LTR-retrotransposons, non-LTR retrotransposons, and non-autonomous retrotransposons have caused disease frequently in mice, but infrequently in humans. Although many of these elements are defective, a number of mammalian non-LTR retrotransposons of the L1 type are capable of autonomous retrotransposition. The mechanism by which they retrotranspose and in turn aide the retrotransposition of non-autonomous elements is being elucidated.

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Animals Disease Humans Interspersed Repetitive Sequences Mutagenesis, Insertional Journal Article Research Support, U.S. Gov't, P.H.S.Review

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H H Kazazian. 1998. Mobile elements and disease.. https://doi.org/10.1016/s0959-437x(98)80092-0

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