[Mycophenolate mofetil].

D Abramowicz; N Broeders; M Wissing; J Sternon

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PubMed · 9697397

[Mycophenolate mofetil].

D Abramowicz·N Broeders·M Wissing·J Sternon

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Abstract

Mycophenolate Mofetil (MMF) is a new immunosuppressive agent that selectively inhibits the proliferation of T and B lymphocytes. The use of MMF in renal transplantation significantly reduced the incidence of acute rejection episodes in the first year after transplantation. The main toxicities of MMF are the occurrence of diarrhea and leucopenia. This potent immunosuppressive agent is devoid of the nephrotoxicity of cyclosporin and of the multiple adverse effects of corticosteroids. Clinical trials are currently in progress to assess whether the use of MMF will allow the discontinuation of cyclosporine or corticosteroid therapy without leading to an increased risk of rejection. If results were positive, MMF would represent a significant advance in the field of renal transplantation.

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Acute Disease Adrenal Cortex Hormones B-Lymphocytes Cell Division Clinical Trials as Topic Cyclosporine Diarrhea Graft Rejection Humans Immunosuppressive Agents Incidence Kidney Kidney Transplantation Leukopenia Mycophenolic Acid Risk Factors T-Lymphocytes Journal Article

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D Abramowicz, N Broeders, M Wissing, J Sternon. 1998. [Mycophenolate mofetil].. https://pubmed.ncbi.nlm.nih.gov/9697397/

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