PubMed · 9713242
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1998. Kava.. https://pubmed.ncbi.nlm.nih.gov/9713242/
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At the menopause outpatient unit among 100 patients with climacteric problems 50 were treated with continuous hormone replacement therapy alone (Group A), and in 50 other cases were given a combination of a half dose hormone replacement therapy (HRT) and anxiolytic drug (Group B). After a 3 month treatment period the complaints were reduced at the same extent in both groups. The frequency of the side effects was similar in both groups. The combination of a reduced dose of HRT and an anxiolytic drug can be an alternative treatment to patients refusing HRT because of cancerophobia or side effects and to those, whom the reduced dose of HRT might be sufficient to avoid climacteric complaints.
Benzodiazepines are widely prescribed for a variety of conditions, particularly anxiety and insomnia. They are relatively safe and, with overdose, rarely result in death. However, used chronically, benzodiazepines can be addicting. These agents are often taken in combination with other drugs of abuse by patients with addiction disorders. In such patients, alternatives to benzodiazepines may be preferable and may include antidepressants, anticonvulsants, buspirone, antihypertensive agents and the newer neuroleptic medications. Caution must be used when prescribing benzodiazepines to patients with a current or remote history of substance abuse.
The chiral separation of lorazepam was achieved on a chiral column with UV and circular dichroism (CD) detection. The good resolution of lorazepam enantiomers was obtained on the column of beta-cyclodextrin derivative immobilized silica gel under reversed-phase conditions. The enantiomeric separation and identification of lorazepam were succeeded by CD detector. The method described allows the quantitation of the stereoisomers of lorazepam in human plasma following the administration of a therapeutic dose of the racemic drug. Chiroptical detection is useful for the pharmacokinetic study of chiral drugs.