PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 973072

[Major histocompatibility system in multiple sclerosis].

J Oger·O Sabouraud·R Fauchet·N Genetet·F Menault·B Genetet
View original source ↗Export metadata ↓

Abstract

The comparison of Histocompatibility Testing in 82 MS Patients and 368 controls is presented. The increase in HL-A7 and decrease in HL-A12 are confirmed. A significant increase in HL-A8 is reported. Mixed Lymphocyte Reaction confirms the LD7a increase (19 out of 24 Multiple Sclerosis patients tested); 100% of the patients bearing the HL-A7 determinant are found to be LD7a. The presence of specific Immune Response genes in Multiple Sclerosis is discussed.

Explore related subjects

Histocompatibility AntigensHumansMultiple SclerosisEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Oger, O Sabouraud, R Fauchet, N Genetet, F Menault, B Genetet. 1976. [Major histocompatibility system in multiple sclerosis].. https://pubmed.ncbi.nlm.nih.gov/973072/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2004

Identification of membrane proteins differentially expressed in human papillomavirus type 16 E5-transfected human keratinocytes by nanoelectrospray ionization mass spectrometry.

Membrane proteins differentially expressed in human papillomavirus type 16 (HPV-16) E5-transfected HaCaT cells have been identified. Membrane proteins were isolated and separated by two-dimensional gel electrophoresis. Spots showing quantitative differences between E5-transfected and control cells were extracted and the proteins were identified by nanoelectrospray ionization mass spectrometry. A total of 24 spots was analysed. Among the proteins showing differential expression, a decreased amount of calnexin and increased expression of hsp70, proteins both involved in maturation and transport of MHC class I complexes to the plasma membrane, were noticed. These findings correlate with the decreased surface expression of MHC class I molecules described in E5-expressing cells, HPV-positive cervical lesions and cervical carcinomas. These results stress the value of the proteomic approach, as used here in the experimental design, which allows the correlation of changes in host gene expression with biological functions of viral genes.

Histocompatibility Antigens↗
PubMed2003

Molecular interactions: stiff or floppy (or somewhere in between?).

Recognition of MHC and MHC-like molecules by both natural killer (NK) and T cell receptors (TCR) reveals remarkable degeneracy. The interaction of the NKG2D NK receptor with several MHC I-like ligands has now been analyzed thermodynamically by McFarland and Strong, who suggest that a "rigid adaptation" mechanism governs such crossreactivity. This contrasts with "induced fit" that accounts for TCR adaptation to multiple MHCp ligands.

Histocompatibility Antigens↗