[Impaired kidney function in lithium therapy].

L Gabutti; M Gugger; H P Marti

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PubMed · 9789472

[Impaired kidney function in lithium therapy].

L Gabutti·M Gugger·H P Marti

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Abstract

Long-term therapy with lithium may be associated with a broad spectrum of functional and structural side-effects in the kidney. Among these features, nephrogenic diabetes insipidus is the most frequent and it can be expected to occur in 20-70% of the patients. Diabetes insipidus is the result of a lithium induced resistance of collecting ducts to antidiuretic hormone. Additional functional disturbances are represented by renal tubular acidosis and consequences of hypercalcemia. Structural alterations of the kidney have a rare occurrence. In the literature, there are accounts of chronic tubulo-interstitial nephritis, acute tubular necrosis and few cases of glomerulopathies. Our report of a patient with chronic interstital nephritis is supplemented by a brief discussion of the diverse picture of the nephrotoxicity of lithium.

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Antimanic Agents Biopsy Bipolar Disorder Female Humans Kidney Kidney Failure, Chronic Lithium Carbonate Middle Aged Nephritis, Interstitial Case Reports English Abstract Journal Article Review

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L Gabutti, M Gugger, H P Marti. 1998. [Impaired kidney function in lithium therapy].. https://pubmed.ncbi.nlm.nih.gov/9789472/

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