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PubMed · 9818547

Complement diversity: a mechanism for generating immune diversity?

J O Sunyer·I K Zarkadis·J D Lambris
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Abstract

Unlike mammalian species, several cold-blooded species have been shown to possess multiple forms of complement components. The multiple forms of C3 characterized in several fish species can bind with different specificities to various complement-activating surfaces. Here, Oriol Sunyer, Ioannis Zarkadis and John Lambris explore the possible advantages conferred by having multiple forms of individual complement proteins in a single organism.

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AnimalsBiological EvolutionComplement C3Complement System ProteinsElectrophoresis, Polyacrylamide GelErythrocytesFishesGenetic VariationImmunity, InnatePhylogenyRabbitsSheepZymosanJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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J O Sunyer, I K Zarkadis, J D Lambris. 1998. Complement diversity: a mechanism for generating immune diversity?. https://doi.org/10.1016/s0167-5699(98)01341-3

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