PubMed · 9822936
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
D N Slater. 1998. Why classify basal cell carcinomas?. https://doi.org/10.1046/j.1365-2559.1998.00222.x
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
While ultraviolet (UV) exposure is thought to be a major risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma, more recent research has focused on genetic factors predisposing to these cancers. UV constitutes an oxidative stress with generation of free radicals, leading to lipid and DNA damage and gene mutation. It could therefore be hypothesized that individual ability to deal with these products may be important in cutaneous carcinogenesis. It is clear from recent studies that polymorphisms in detoxifying enzyme genes are important in determining susceptibility to skin cancer. The magnitude of effect in BCC is similar to that seen with many other previously described risk factors. However, uncertainties exist regarding the phenotypic consequences of some of these polymorphisms and relevant substrates. This review describes the influence of polymorphisms in detoxifying enzymes in determining susceptibility to skin cancer (in particular to BCC) and give a brief overview of the biochemistry of the detoxification process.
Explore the source record for details and available documents.
A case of vulvar basocellular carcinoma in a 49-year-old woman is presented. The treatment of choice is local excision and the prognosis in general is excellent. The importance of taking biopsies from atypical vulvar lesions is underlined.