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PubMed · 9855197

Principles of tissue engineering applied to programmable osteogenesis.

J H Brekke·J M Toth
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Abstract

This article presents a strategy for design, engineering, and fabrication of a bioresorbable, manufactured bone graft substitute (BGS) device. The approach is based on established precepts of osteogenesis, molecular biology of hyaluronic acid and osteoinductive proteins, and theoretical preformance criteria for such a device collated from the literature of 1991 to 1996. Application of this design and engineering strategy results in a composite device consisting of a D,D-L,L-polylactic acid macrostructure optimized to the architecture of cancellous bone, a microstructure composed of a filamentous velour of hyaluronan and a recombinant human bone morphogenetic protein 2 (rhBMP-2). The performance of this construct was tested in vivo in the dog, intertransverse process, spinal fusion model and in a critical sized defect of the rabbit radius. Data from these studies are used to illustrate principle points of the design and engineering concept.

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AnimalsBiocompatible MaterialsBone SubstitutesBone and BonesCells, CulturedChemical PhenomenaChemistry, PhysicalEngineeringHumansHyaluronic AcidLactic AcidMaterials TestingMicroscopy, Electron, ScanningOsteoblastsOsteogenesisPhenotypePolyestersPolymersRabbitsSpinal FusionSurface PropertiesJournal ArticleResearch Support, Non-U.S. Gov't

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J H Brekke, J M Toth. 1998. Principles of tissue engineering applied to programmable osteogenesis.. https://doi.org/10.1002/(sici)1097-4636(199824)43%3A4%3C380%3A%3Aaid-jbm6%3E3.0.co%3B2-d

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