PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 990164

Lung cancer model for studying multi-step metastasis.

W I Onuigbo
View original source ↗Export metadata ↓

Abstract

The sequence of the spread of cancer has been a problem for over a century. A simple model based on lung cancer is proposed. It utilizes three well known facts: that lung cancer may selectively attack the adrenals, that such adrenal deposits may or may not invade the outflow venous tract and that contralateral lung deposits are uncommon in this cancer. Therefore any sequence of spread from the ipsilateral lung to the adrenal glands and thence to the contralateral lung merits attention. Its study might throw light on the laws governing multi-step metastasis in man.

Explore related subjects

Adrenal Gland NeoplasmsAdrenal GlandsHumansLungLung NeoplasmsModels, BiologicalNeoplasm MetastasisJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

W I Onuigbo. 1976. Lung cancer model for studying multi-step metastasis.. https://doi.org/10.1016/0007-0971(76)90041-3

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2008

Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses.

Opsoclonus-myoclonus-ataxia-syndrome (OMS) represents a rare neuroblastoma-associated paraneoplastic syndrome that commonly results in neurologic deficits despite tumor resection and immunosuppressive therapy. We describe the response of five such children to high-dose dexamethasone pulses including two patients in whom previous glucocorticoids, rituximab, and cytostatic drugs were not successful. All patients had MYCN non-amplified tumors that were detected 1 to 7 months after the onset of the OMS or ataxia. This treatment resulted in a good partial response in three and in complete remission in two patients. Our results show that dexamethasone pulses are likely to be useful for both, first-line- and salvage-therapy for OMS-patients.

Adrenal Gland Neoplasms↗
PubMed2007

Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene.

INTRODUCTION: Malignant paragangliomas have been well described in carriers of mutations of the succinate dehydrogenase B (SDHB) gene, but have rarely been associated with mutations in the succinate dehydrogenase D (SDHD) gene. AIM: The aim of the study was to report the different clinical expression patterns of malignant paragangliomas in five patients with SDHD (D92Y) mutations observed in approximately 200 SDHD (D92Y) mutation carriers followed in our institution. RESULTS: Metastasis and/or local tumor invasion was documented 0 (n=2), 1, 18, and 30 yr after the initial diagnosis of paraganglioma. Malignancy was proven by paraganglioma bone metastases (n=2), intrathoracic paraganglioma with lymph node metastases, locally invasive head-and-neck paraganglioma with destruction of the petrosal bone, and locally invasive paraganglioma of the bladder with lymph node metastases. Four of the five patients developed catecholamine excess during follow-up due to intraadrenal paraganglioma (pheochromocytoma) (n=1), extra adrenal paraganglioma (n=2), and presumed subclinical disease (n=1). CONCLUSION: SDHD mutations (D92Y) are associated with malignant paragangliomas and catecholamine excess with remarkable interindividual variations despite the same mutation. We estimate that the prevalence of malignancy in carriers of D92Y mutations is at least 2.5%.

Adrenal Gland Neoplasms↗