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PubMedDate not supplied

Collagenous colitis.

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Colitis↗
PubMed1996

[Collagenous colitis and chronic diarrhea].

A 68-year-old woman presented with a 4-month history of watery diarrhoea and weight loss. Radiological, analytical, endoscopic studies and intestinal biopsy were all normal. Biopsy specimens of the colonic mucosa showed the pathological features of collagenous colitis. The patient initially received mesalazine, 2 g/day, without clinical improvement; symptoms resolved following therapy with prednisone, 30 mg daily. After 2 months of prednisone therapy the diarrhea and weight loss resolved. A second colonoscopy performed 13 month after the original procedure revealed persistence of the histologic features of collagenous colitis. The diagnostic importance of total colonoscopy with multiple biopsies in a normal-appearing colon in patients with unexplained chronic watery diarrhea is stressed. Biopsies taken only from the rectum cannot exclude the diagnosis. Collagenous colitis should be considered in the differential diagnosis of chronic diarrhoea.

Aged↗
PubMed1980

Collagenous colitis: an unrecognised entity.

A patient is reported with chronic abdominal pain, diarrhoea, and associated radiological and endoscopic abnormalities of the sigmoid colon. Light and electron microscopic study of colorectal mucosa showed abnormal collagenous thickening of the subepithelial basement membrane. The authors felt that the clinical and morphological features justified a diagnosis of collagenous colitis. Review of the literature suggested that collagenous colitis was still an unrecognised entity.

Colitis↗
PubMedDate not supplied

[Collagenous colitis].

The authors report two new observations of collagenous colitis. In both cases the signs were of functional colonopathy, and the diagnosis was only made after rectal and colic biopsies. In one case, electron microscopy revealed that the collagen band was independent of the epithelial membrane. The collagenous deposit contained many nerve endings, which seems to suggest an inflammatory origin of the disease. The clinical condition of a female patient was greatly improved by mepacrine, but the histological lesions remained unchanged.

Colitis↗
PubMed2006

Clinical course of collagenous colitis over a period of 10 years.

AIM: The aim of this study was to evaluate the long-term outcome of patients with collagenous colitis 10 years after the diagnosis. PATIENTS AND METHODS: In 1989/1990, 65 patients were diagnosed to have collagenous colitis. Initially and after an interval of ten years these patients were asked to complete a questionnaire including onset and duration of diarrhea, stool frequency and consistency, other gastrointestinal symptoms including weight loss, drug history, treatment response and concomitant diseases. RESULTS: Questionnaires from 47 patients (72.3 %) (female 40; mean age 68 years, range 41 - 95 years) were available for analysis. After a follow-up of ten years, 11 patients (23.4 %) had persistent diarrhea with no change of frequency and consistency compared to baseline. Four patients (8.5 %) showed a reduction of diarrhea frequency of at least 50 %. Diarrhea was resolved in 23 patients (48.9 %) during the follow-up period. Of those, 20 patients received anti-inflammatory treatment. After a complete resolution of diarrhea during the long-term follow-up, 9 patients (19.2 %) showed recurrence of diarrheal symptoms. None of the patients developed any malignancies of the GI-tract. CONCLUSION: The long-term outcome of CC is benign with a resolution of diarrhea in up to 50 % of patients receiving anti-inflammatory treatment. About 30 % of patients may experience persistent diarrhea even 10 years after diagnosis. Our data confirm that CC is a chronic disorder with a variable course of symptoms during a long-term follow-up.

Adult↗