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At least 343 records · Page 19Linked to original sources
PubMed1983

Breastfeeding and oral contraceptives: Tasmanian survey.

A survey of 772 Tasmanian mothers was carried out to determine whether there was any connection between the mother's use of oral contraceptives and her ability to breastfeed her child. It was found that 80% of the 243 mothers combining breastfeeding with the use of oral contraceptives were able to breastfeed their children for at least 3 months. Of these, all but 15 mothers used pills containing only progestagen. It is concluded that the progestagen-only oral contraceptive is compatible with lactation and that a mother using this type of pill will probably be able to breastfeed her baby.

Adult↗
PubMed1982

Outcome in patients with post-pill amenorrhoea.

Ninety-six patients who developed amenorrhoea following the use of oral contraceptives were studied in two groups; one with a history of regular periods and the other with irregular periods prior to the use of oral contraceptives. Pregnancy rates were similar in patients with and without a previous history of menstrual dysfunction. Thirty-nine of 47 patients who desired pregnancy and in whom there was no definable factor inhibiting pregnancy, succeeded in conceiving.

Adolescent↗
PubMed1986

The circadian pattern of melatonin and its positive relationship with progesterone in women.

To investigate the possible role of melatonin in the regulation of the human menstrual cycle, the circadian pattern of melatonin was determined in the follicular and luteal phases of 10 normal women. Four-hourly sampling was used to derive a melatonin index which described the total exposure to melatonin for 24 h. This sampling procedure adequately represented the circadian melatonin output and demonstrated that pulses of melatonin secretion, inconsistent with a measured half-life of 47 min, did not exist. A significant increase (P less than 0.001) in the melatonin index was found in the luteal phase compared to that in the follicular phase. To investigate the influence of exogenous progestins on the melatonin pattern, repeated 24-h profiles were measured in 8 women taking the 3-phase contraceptive pill. There was a significant increase (P less than 0.01) in the melatonin index associated with an increase in the dose of progestin. These results are consistent with a positive relationship between melatonin and progesterone and suggest that changes in the circadian pattern of melatonin secretion, rising during the luteal phase with a fall before ovulation, may act as a modulator of cyclicity.

Administration, Intranasal↗
PubMed1983

Ultrastructure of endometrium of postmenopausal patients on two modes of hormonal therapy: estrone sulfate with or without MPA.

The response of human postmenopausal endometrium to standard, oral doses of an estrogen alone (estrone sulfate) and to an estrogen plus a progestin (medroxyprogesterone acetate; MPA) was evaluated by scanning electron microscopy and transmission electron microscopy. Endometrial biopsies were obtained over a 4-year period from 12 patients with well-established ovarian failure. Biopsies were taken before the initiation of therapy and during each mode of hormonal treatment. The ability of estrone sulfate alone to stimulate growth of the endometrium was shown during the 1st treatment cycle when the atrophic epithelial cells transformed into tall columnar cells which synthesized and released some secretory products. Unopposed estrogen therapy led to excessive ciliation and breakthrough bleeding. Addition of MPA to the estrone sulfate regimen produced a progestational endometrium. The epithelial cells had ultrastructural features of those in normal postovulatory endometrium, including nucleolar channel systems. MPA elicited deciliation and transformation of ciliated cells into secretory cells. Stromal cells hypertrophied, the vascular endothelium thickened, and bleeding subsided. Estrogen-progestin therapy as tremendously more physiological than unopposed estrogen therapy.

Biology↗
PubMed1985

Sustained release systems for ethinylestrogens.

The immunoreactive serum concentration of ethinylestradiol (EE) was measured by a specific radioimmunoassay after a single intramuscular administration of a combined preparation of Norethindrone (NET) and Mestranol (ME). The mean peak serum value for the 6 women studied was 278.5 pm/m1/m2 of body surface area (BSA), and was reached 11.17 days after dosing, with a half-life of absorption (T1/2 abs) of 9.37 days. In 5 out of 6 subjects EE was detectable in the circulaton for 21 days after injection. The mean serum concentration time curve was calculated in 2720.67 pg/day/m1/m2. The shape of the 1-21 day concentration-time curve shows a sustained release pattern, suitable for a long acting fertility regulation method.

Biology↗