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At least 37 records · Page 2Linked to original sources
PubMed1996

MIB-1 immunoreactivity reveals different labelling in low-grade and in malignant epithelial neoplasms of the choroid plexus.

MIB-1 immunohistochemistry was carried out on a retrospective biopsy series of epithelial choroid plexus neoplasms in order to assess the proliferation rate of tumour cells. The material included 14 cases of papilloma (WHO grade I) and five cases of carcinoma (WHO grade III). There was one recurrent tumour in the papilloma group, while three patients with carcinoma experienced recurrence. Choroid plexus obtained at autopsy from paediatric and adult patients with unrelated diseases served as control. The average MIB-1 labelling index of choroid plexus papillomas was 3.7%, while that of carcinomas was 14%, and that of normal choroid plexus was 0.02% to 0.06%. The age and sex of the patients as well as the tumour localization were not found to influence MIB-1 reactivity. The labelling index of recurrent lesions was not significantly different from that of the corresponding primary tumours. High MIB-1 labelling indices were associated with less favourable post-operative outcome in choroid plexus carcinomas and in one papilloma with atypical histology. However, most tumours with atypical histological features did not exhibit distinctive MIB-1 labelling indices. Analysis of growth fraction by MIB-1 immunohistochemistry may prove a useful ancillary method for assessing the malignant potential of choroid plexus neoplasms.

Adolescent↗
PubMed1990

Subepithelial basement membrane deposition and intermediate filament expression in choroid plexus neoplasms and ependymomas.

The pattern of basement membrane deposition was investigated in benign and malignant choroid plexus tumours using an immunocytochemical method to detect laminin, an intrinsic basement membrane component. The results were compared with intracranial ependymomas and myxopapillary ependymomas of the filum terminale. Expression of the intermediate filaments cytokeratin and glial fibrillar acidic protein (GFAP) and the epithelial marker carcino-embroyonic antigen (CEA) was also assessed. Laminin was detected in a subepithelial location in all the choroid plexus tumours but in none of the ependymomas, although basement membrane fragmentation was seen in the choroid plexus carcinomas. In contrast, GFAP was present in all the types of tumour examined. Cytokeratin (as detected by CAM 5.2) was present in all the choroid plexus lesions and also in the ependymomas arising in the spinal canal. CEA was not detected. We conclude that immunostaining for laminin assists distinction between choroid plexus tumors and papillary ependymomas and between benign and malignant choroid plexus tumours.

Basement Membrane↗
PubMed1983

Childhood choroid plexus neoplasms. A study of 14 cases less than 2 years old.

Fourteen children less than 2 years old with choroid plexus papilloma (CPP) were studied. Of these patients nine had the tumor in the lateral ventricles (LV), three in the fourth ventricle (4th V), one in the third ventricle (3rd V) and one in the third and left lateral ventricle (LLV). Ten cases showed benign CPP, three cases malignant CPP, and one case had a venous malformation of the choroid plexus (VMCP). Computed tomography (CT) was the best method for neuroradiological study, although a very small CPP in the 3rd V was not detected in an early study. Malignant and benign CPP can be differentiated with CT, especially if the study is performed with contrast media. Pneumoencephalography must be rejected because it is very dangerous and may be the cause of death in some cases. The follow-up of patients with CPP showed a poor prognosis, even after correctly removing the tumor and inserting a shunt.

Cerebral Ventricle Neoplasms↗
PubMed1999

Ultrasonography of metastases and melanomas of the choroid.

Choroidal metastases and melanomas are the most common intraocular neoplasms. Choroidal metastases may appear clinically similar to other amelanotic tumors, and the diagnosis may be difficult in the absence of a history of extraocular malignancy. Ultrasonography, using A- and B-mode criteria, offers an opportunity for high accuracy in the diagnosis of choroidal tumors. However, a considerable overlapping of ultrasonographic parameters, such as tumor solidity, vascularity, and choroidal excavation, has been demonstrated for choroidal melanomas and metastases. We have found that choroidal metastases are characterized by a significantly lower height-to-base ratio than melanomas, whereas reflectivity is significantly higher in metastases. Thus the combined use of height-to-base ratio and reflectivity provides a highly significant differentiation between choroidal melanomas and metastases. This observation has further improved the diagnostic value of ultrasonography in the differentiation of choroidal tumors.

Choroid Neoplasms↗
PubMed1993

[Acute glaucoma: first manifestation of malignant melanoma of the choroid].

Most malignant melanomas of the choroid are discovered during a routine examination of the fundus or following visual symptoms. More rarely, increased intraocular pressure or acute glaucoma represent the first signs of intraocular malignant melanoma. A 66-year-old female presented with an unilateral acute closed angle glaucoma associated with rubeosis iridis and total retinal detachment. Using ultrasonography, a choroidal neoplasm was diagnosed. Histopathologic examination of the enucleated globe confirmed the diagnosis of a necrotic malignant melanoma of the choroid with subretinal hemorrhage. Every blind eye with opaque media requires ultrasonographic and, if enucleated, histopathologic examination.

Acute Disease↗
PubMed1994

Intracranial vascular tumors.

The study of intracranial vascular tumors is of significant importance because these tumors may stimulate vascular malformations, infarctions, or infections. This article describes vascular tumors and discusses their appearance on MR imaging studies. Choroid plexus neoplasms, primitive neuroectodermal tumors, hemangioblastoma and other disorders are discussed.

Adult↗