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Acquired immunodeficiency syndrome/human immunodeficiency virus risk behavior among gay men in small cities. Findings of a 16-city national sample.

BACKGROUND: Most research on acquired immunodeficiency syndrome has been conducted in several of the country's largest cities, and little is known about the current level of human immunodeficiency virus risk taking among gay men in other geographical areas. The purpose of this study was to determine the frequency of risk behavior practices among gay men in smaller communities. METHOD: A large sample of men who patronized gay bars in 16 small and moderate-size cities drawn from six states in four different regions of the country was surveyed to determine the frequency of high-risk behavior and factors influencing risk taking. Eighty-five percent of men in all cities' bars completed all survey measures. The community samples were 1991 men; mean age, 31.3 years; mean education, 10.6 years; 90% were white and 10% were of other ethnicities. All participants provided detailed information on their sexual behavior practices over the preceding 2 months and completed measures assessing their perceived peer norms concerning safer sex practices and risk avoidance, intentions to avoid risk, personal risk estimation, acquired immunodeficiency syndrome risk knowledge, perceived threat of acquired immunodeficiency syndrome/human immunodeficiency virus, and serostatus testing history. RESULTS: High-risk patterns were still common among gay men in these smaller cities; nearly one third of all men had engaged in unprotected anal intercourse an average of eight times in the past 2 months, usually outside monogamous relationships. High-risk behavior was most strongly associated with beliefs that safer sex practices would not be well accepted by peers, weak intentions to use condoms, underestimation of personal vulnerability to the acquired immunodeficiency syndrome, younger age, and higher levels of overall sexual activity. Nine percent of men tested said they were seropositive. CONCLUSIONS: Growing human immunodeficiency virus prevalence and continued high rates of risk behavior indicate that a new "front line" for human immunodeficiency virus prevention among homosexually active men has shifted to the country's smaller cities. Community prevention efforts in these areas are urgently needed to avert sharp increases in future human immunodeficiency virus infections in this population.

Acquired Immunodeficiency Syndrome↗

[Autoradiographic investigations on the effect of city smog extract on DNA synthesis and cell cycle of mammalian cells in vitro. I. Effect of city smog extract on DNA synthesis of kidney- and embryonic cells of the golden hamster in vitro (author's transl)].

We analysed the effect of city smog extract from Düsseldorf on DNA synthesis of mammalian cells in vitro. Airborne dust was extracted with aceton and thereafter transferred to dimethylsulfoxide. Dosage was calculated according to the benzo(a)pyrene content. We used logarithmically growing cultures of hamster kidney and embryonic cells. DNA synthesis was determined autoradiographically by incorporation of 3H-Thymidine. We found that city smog extract exerted a dose-dependent cytotoxic effect leading to a decrease of DNA synthesizing cells. High concentrations of city smog extract induced cell necrosis and suppressed DNA synthesis completely. Moderate doses of extract caused a dose-dependent, but temporary cessation of DNA synthesis. Cells resumed DNA synthesis after a certain delay. Low concentrations of city smog extract induced no detectable effects. Inhibition of DNA synthesis was evident already one hour after addition of extract. Therefore a direct effect on DNA metabolism could be supposed. Furthermore, exposed cultures demonstrated a delay in entrance of new cells into the DNA synthesis. Alterations in DNA synthesis could be of great importance for carcinogenesis, especially if we take in consideration the content of carcinogens in city smog extract.

Animals↗

[Autoradiographic investigations on the effect of city smog extract on DNA synthesis and cell cycle of mammalian cells in vitro. II. Alterations of the cell cycle of hamsters kidney cells and hamster embryonic cells in presence of city smog extract (author's transl)].

We used the autoradiographic method according to Quastler and Sherman to analyse alterations in the cell cycle under the influence of city smog extracts. Investigations were performed on logarithmically growing cultures of kidney and embryonic cells of the Syrian golden hamster. Low concentrations of city smog extracts (0.125 micrograms/ml Benzo(a)pyren-equivalent) induced a remarkable delay of cell entrance into DNA-synthesis. Furthermore a considerable prolongation of generation time and phase of DNA-synthesis was detected. The number of mitosis was strongly reduced. Already a doubling of concentration of city smog extract caused an almost complete breakdown of the cell cycle and a disappearing of mitosis for a time period of 10 hours. Our results strongly indicate that city smog extracts lead to a severe alteration of the molecular biology of the cell. Taking this in consideration, it can be assumed that a long term exposure of human beings to the city smog could induce an injury of health.

Air Pollutants↗

Heart disease mortality in cities of Latin America and in cities and regions of England and Wales.

Death rates from heart disease in cities and regions of England and Wales, based on death certificates for 1963, are compared with death rates from the same causes in 10 Latin American cities, San Francisco, USA, and Bristol, England, derived from the Inter-American Investigation of Mortality which obtained histories and clinical records of fatal illnesses for the years 1962-64 by a sampling method. Death rates in Bristol derived from the 2 sources showed an agreement close enough to justify comparisons between official rates for England and Wales and the data for the Latin American cities.Comparing standardized death rates for males in the Latin American cities with those for the corresponding populations in the English conurbations and cities, the ratio for coronary disease was found to be 0.4; for other degenerative heart disease it was 1.0; for hypertensive heart, 2.2; for other heart disease, 1.5. The corresponding ratios for females were: 0.55, 1.0, 3.0, and 1.7, respectively. When the hospital regions of England and Wales were included, a geographical pattern could be seen, particularly for males, the highest rates for coronary and degenerative heart disease being found in northern England and the lowest rates in central and western cities of Latin America. For hypertensive and other heart disease the pattern was different.Standardized sex ratios for total heart disease mortality at ages from 45 to 74 years in 30 countries are largely affected by the proportions of deaths attributed to arteriosclerotic and degenerative disease but they suggest that geography, country of origin and possibly climate are also factors that differentially affect the sexes and, in consequence, affect the sex ratios.

Adolescent↗

The avoidable health effects of air pollution in three Latin American cities: Santiago, São Paulo, and Mexico City.

Urban centers in Latin American often face high levels of air pollution as a result of economic and industrial growth. Decisions with regard to industry, transportation, and development will affect air pollution and health both in the short term and in the far future through climate change. We investigated the pollution health consequences of modest changes in fossil fuel use for three case study cities in Latin American: Mexico City, Mexico; Santiago, Chile; and São Paulo, Brazil. Annual levels of ozone and particulate matter were estimated from 2000 to 2020 for two emissions scenarios: (1) business-as-usual based on current emissions patterns and regulatory trends and (2) a control policy aimed at lowering air pollution emissions. The resulting air pollution levels were linked to health endpoints through concentration-response functions derived from epidemiological studies, using local studies where available. Results indicate that the air pollution control policy would have vast health benefits for each of the three cities, averting numerous adverse health outcomes including over 156,000 deaths, 4 million asthma attacks, 300,000 children's medical visits, and almost 48,000 cases of chronic bronchitis in the three cities over the 20-year period. The economic value of the avoided health impacts is roughly 21 to 165 billion Dollars (US). Sensitivity analysis shows that the control policy yields significant health and economic benefits even with relaxed assumptions with regard to population growth, pollutant concentrations for the control policy, concentration-response functions, and economic value of health outcomes. This research demonstrates the health and economic burden from air pollution in Latin American urban centers and the magnitude of health benefits from control policies.

Adolescent↗

Two New York City hospitals' surgical response to the September 11, 2001, terrorist attack in New York City.

BACKGROUND: We describe the surgical response of two affiliated hospitals during the day of, and week following, the September 11th, 2001 terrorist attack at the World Trade Center in New York City. The city of New York has 18 state designated regional trauma centers that receive major trauma victims. The southern half of Manhattan is served by a burn center, two regional trauma centers, and a community hospital that is an affiliate of one of the regional trauma centers. This report accounts for the surgical response by a regional trauma center (Hospital A, located 2.5 miles from the World Trade Center) and its affiliate hospital (Hospital B, located 5 city blocks from the World Trade Center) on September 11th when two commercial jets crashed into the Twin Towers at the World Trade Center mall. METHODS: Hospital A maintained a concurrent log of patients received during the first 5 hours, the first day, and the first week after the disaster which was kept by the Surgical Triage Officer. The trauma registry completed and verified this data by September 18th. Hospital B collected its data by hand counting and verification by chart review. Both hospitals, A and B, had established disaster plans that were implemented. RESULTS: Nine hundred eleven patients were received by two affiliated hospitals from the World Trade Center attack. Seven hundred seventy six patients (85%) were walking wounded, sustaining mild inhalation and eye irritant injuries. One hundred thirty five (15%) were admitted with 18 (13%) of these undergoing surgery. Twenty two of the 23 transfers were from the community hospital to specialized orthopedic or burn centers. Of the 109 patients admitted to Hospital A, 30 were to the surgical service. The mean ISS score of these patients was 12. There were 4 deaths (within minutes of arrival at the hospital) and 6 delayed deaths (day 1-14). Excluding walking wounded and DOAs, the critical mortality rate was 37.5% overall. CONCLUSION: The September 11th, 2001, terrorist attack in New York City, involving two commercial airliners crashing into the World Trade Center, led to 911 patients received at two affiliated hospitals in lower Manhattan. One hospital is a regional trauma center and one was an affiliate community hospital. Eighty five percent of the patients received were walking wounded. Of the rest, 13% underwent surgical procedures with an overall critical mortality rate of 37.5%.

Aviation↗

A tale of two cities: tuberculosis control in Nicaragua and New York City.

The tuberculosis (TB) control programs in Managua, Nicaragua, and New York City are compared, including their methods of case finding, treatment, follow-up, data collection, and cure rate. In all areas, Managua's program has proven more successful than New York City's, despite the enormously greater resources available in the latter. Nicaragua's TB program concentrated on active cases, had immediately available diagnosis with a microscope in each clinic, had nearly 100% directly observed therapy during at least the first 2 months, and sent its workers into the field immediately after a patient broke an appointment. New York City's program has fewer than 2% of its patients under directly observed therapy, operates a laboratory and clinic system in which obtaining sputum smear results requires 10 to 20 days, and has delays of weeks to months in returning patients to supervision after a broken appointment. The numbers speak for themselves: the Nicaraguan TB program cured nearly 80% of the patients enrolled in the mid-to late 1980s, whereas New York City's program rarely cured 50% and in some areas cured less than 15%.

Adult↗

Characteristics of inner-city children with asthma: the National Cooperative Inner-City Asthma Study.

Asthma morbidity has increased dramatically in the past decade, especially among poor and minority children in the inner cities. The National Cooperative Inner-City Asthma Study (NCICAS) is a multicenter study designed to determine factors that contribute to asthma morbidity in children in the inner cities. A total of 1,528 children with asthma, ages 4 to 9 years old, were enrolled in a broad-based epidemiologic investigation of factors which were thought to be related to asthma morbidity. Baseline assessment included morbidity, allergy evaluation, adherence and access to care, home visits, and pulmonary function. Interval assessments were conducted at 3, 6, and 9 months after the baseline evaluations. Over the one-year period, 83% of the children had no hospitalizations and 3.6% had two or more. The children averaged 3 to 3.5 days of wheeze for each of the four two-week recall periods. The pattern of skin test sensitivity differed from other populations in that positive reactions to cockroach were higher (35%) and positive reactions to house dust mite were lower (31%). Caretakers reported smoking in 39% of households of children with asthma, and cotinine/creatinine ratios exceeded 30 ng/mg in 48% of the sample. High exposure (> 40 ppb) to nitrogen dioxide was found in 24% of homes. Although the majority of children had insurance coverage, 53% of study participants found it difficult to get follow-up asthma care. The data demonstrate that symptoms are frequent but do not result in hospitalization in the majority of children. These data indicate a number of areas which are potential contributors to the asthma morbidity in this population, such as environmental factors, lack of access to care, and adherence to treatment. Interventions to reduce asthma morbidity are more likely to be successful if they address the many different asthma risks found in the inner cities.

Allergens↗

Mouse allergen. I. The prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study.

BACKGROUND: Although mouse allergen is a well-defined cause of IgE-mediated hypersensitivity in occupational settings, it has not been well studied in the general population. OBJECTIVE: We sought to determine the prevalence of mouse allergen in inner-city homes. METHODS: A subset of 608 homes from the National Cooperative Inner-City Asthma Study population had dust samples adequate for analysis of mouse allergen. In addition, data regarding the demographics and housing of the subjects were related to the mouse allergen levels. RESULTS: Ninety-five percent of all homes had detectable mouse allergen (Mus m 1) in at least one room, with the highest levels found in kitchens (kitchen: range, 0-618 microg/g; median, 1.60 microg/g; bedroom: range, 0-294 microg/g; median, 0.52 microg/g; television-living room: range, 0-203 microg/g; median, 0. 57 microg/g). By city, 100% of the kitchens in Baltimore had detectable mouse allergen, with the lowest percentage (74%) in Cleveland. Mouse allergen levels correlated among rooms (R = 0.65-0. 75). Forty-nine percent of the homes had reported problems with mice within the last year, and 29% of the homes had evidence of mice in one or more rooms on home inspection and had higher levels of mouse allergen (P =.0001). Higher allergen levels were also associated with evidence of cockroach infestation in any room (P =.006). None of the other subject or housing demographics evaluated were associated with a higher prevalence or level of mouse allergen. CONCLUSIONS: We conclude that mouse allergen is widely distributed in inner-city homes and that cockroach infestation is associated with high mouse allergen levels.

Allergens↗

House dust mite allergen levels in two cities in Canada: effects of season, humidity, city and home characteristics.

The homes of 120 patients with asthma, 57 in Vancouver and 63 in Winnipeg, were studied. The characteristics of the homes were assessed by a questionnaire. Dust samples were collected and the indoor relative humidity was measured four times during the year covering all four seasons in both cities. Mite allergen levels were determined using monoclonal antibodies against Der p I and Der f I by the ELISA method. The mean levels of both mite allergens in mattress and floor samples in the homes in Vancouver and in Winnipeg were relatively low for all seasons. Mite allergen levels were found to be associated with city, season and individual home differences. They were significantly higher in Vancouver than in Winnipeg. Der p I and Der f I in mattress samples in both cities and Der f I in floor samples in Vancouver, varied by season. The indoor relative humidity level in the homes in Vancouver were also significantly higher than those in Winnipeg. There was, however, no significant association between the levels of indoor relative humidity and the levels of mite allergens after adjusting for variations in city, season and individual home. Although individual home differences were highly associated with mite allergen levels, only a few home characteristics were found to be related to mite allergen levels such as the type and the age of the home, the type of heating, the use of feather pillows and the number of occupants in the homes. Whether low levels of mite allergens are partially responsible for the relatively low prevalence of childhood asthma in Canada remains to be investigated.

Allergens↗

Asthma prevalence in children living in north Mexico City and a comparison with other Latin American cities and world regions.

Reports of previous studies done without following the international guidelines in different cities of Mexico showed a decrease in asthma prevalence. The aim of this study was to determine the prevalence and severity of asthma symptoms in children and teenagers living in north Mexico City and compare them with those of other Latin American cities and world regions. The cross-sectional survey followed the protocol of the International Study of Asthma and Allergies in Childhood IIIb phase survey. The study population included children 6-7 years old and teenagers 13-14 years old from randomly selected primary and secondary schools. There were 1629 boys and 1582 girls in the group of 6- to 7-year-old children and 2039 boys and 1860 girls in the 13- to 14-year-old group. "Wheezing or whistling in the chest at any time in the past" was present in 19.2% (95% confidence interval [CI], 17.9, 20.6) of the children and in 17.0% (95% CI, 15.8, 18.1) of the teenagers; "wheezing or whistling in the chest in the last 12 months" was reported in 6.8% (95% CI, 5.9, 7.6) of the children and 9.9% (95% CI, 9.0, 10.8) of the teenagers; "asthma ever" was claimed in 4.5% (95% CI, 3.8, 5.2) of the children and 8.0% (95% CI, 7.1, 8.8) of the teenagers. These prevalences were low compared with other ISAAC Latin American surveys and intermediate in comparison with worldwide regional prevalences reported by ISAAC surveys. The prevalence of asthma is low in Mexico City in comparison with other surveyed locations, but the number of patients with asthma makes it an important issue for Mexican public health programs.

Adolescent↗

The big, bad city: mega-city myth?

This paper raises the question of whether or not the virtues of big city size were exaggerated in the literature which appeared in the 1970s with respect to developing country megacities. It examines negative externalities (especially pollution), the capital costs associated with megacity growth, the productivity advantages of large cities, the role of spatial restructuring towards a policentric pattern as a relief to core city congestion, and the problems of metropolitan management (including the appropriate institutional framework). The adoption of constructive policy actions could handle the following problems: that the declining rates of megacity growth may reflect declining productivity advantages; that capital costs of urbanization increase strongly with city size; that there are diseconomies of scale in urban management; that negative externalities may be more severe in developing country megacities in physical but not in imputed monetary damage terms; and that policentric evolution may be hampered by the wrong type of government intervention.

Demography↗

[Analysis of the biological effect of city smog extract. III. Comparative investigations on the effect of city smog extracts on cell replication and DNA-synthesis of kidney cells in vitro from the primate Cercopithecus aethiops (author's transl)].

We analysed the cytotoxic effect of city smog extracts from a heavy industrialized area using kidney cell cultures from the primate Cercopithecus aethiops.--Using logarithmically growing cell cultures we determined cell replication and the rate of DNA-synthesis after incorporation of 3H-thymidine.--In presence of city smog extracts we found a dose dependent reduction of cell replication and of DNA-synthesis. In presence of high concentrations (BP-aquivalent 0.25-0.5 microgram/ml) of city smog extract we found no increase in cell number over a period of 72 h. Under the same conditions hardly any DNA-synthesis was detected.--In presence of middle and low concentrations of city smog extract a dose- and time-dependent increase in cell number and rate of DNA-synthesis was detected.

Animals↗

[Analysis of the biological effect of city smog extract. V. Comparative investigations on the effect of city smog extracts on DNA synthesis of Syrian hamster kidney and embryonic cells and of African green monkey kidney cells in vitro (author's transl)].

We analysed the effect of two samples of city smog extract from Bochum and Duisburg on DNA synthesis of mammalian cells in vitro. As a test system we used tissue cultures of kidney and embryonic cells from the Syrian golden hamster and monkey kidney cells from Cercopithecus aethiops. DNA synthesis of cells was measured by autoradiography using 3H-Thymidine. Both samples of city smog extract exerted a dose-dependent decrease of the rate of DNA synthesis in tissue culture cells. These alterations of nucleic acid metabolism were expressed by a reduction of DNA-synthesizing cells and by a delay of entrance of cells in DNA synthesis. High concentrations of city smog extracts induced a large number of cell necroses. Monkey kidney cells were more sensitive to the toxic action than hamster cells. Furthermore the city smog extract from Duisburg showed a stronger toxic effect than the extract from Bochum.

Air Pollutants↗

[Analysis of the biological effect of city smog extract. I. Cytotoxicity of city smog extract from an urban area and of polycyclic aromatic hydrocarbons on mouse macrophages in vitro (author's transl)].

We analyzed the cytotoxic effect of a city smog extract from a large urban area, employing mouse macrophages in vitro. In parallel experiments we tested carcinogenic and non carcinogenic polycyclic aromatic hydrocarbons: benzo(a)pyrene, 7, 12-dimethylbenzanthracene, pyrene and anthracene. City smog extract induced a dose-dependent reduction of cell viability and an alteration in cell membrane permeability. In contrast to city smog extract the carcinogenic and non carcinogenic polycyclic aromatic hydrocarbons produced no detectable cytotoxic effects in the dose range we analyzed. Possible implications of the cytotoxic effect of city smog extract on the lung are discussed.

Air Pollutants↗

Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles.

The Toxics Exposure Assessment Columbia-Harvard (TEACH) Project characterized personal, indoor, and outdoor concentrations of a suite of volatile organic compounds (VOCs) for high school students living in New York City (NYC) and Los Angeles (LA). This paper presents the analysis of VOC measurements collected indoors and outdoors for 46 students' homes in NYC and for 41 students' homes in LA across two seasons. Dual-sorbent thermal desorption tubes were used for the collection of 15 VOCs and C(18) 2,4-dinitrophenylhydrazine-coated cartridges were used for the collection of seven aldehydes. Air-exchange rates (AERs) were also measured using a perfluorocarbon tracer gas method. The AERs were lower in the winter in both cities, averaging 1 h(-1) in NYC and 1.4 h(-1) in LA, compared with 1.8 h(-1) in NYC in the summer and 2.5 h(-1) in LA in the fall. Higher AERs were generally associated with lower indoor-outdoor ratios with significant differences for the compounds with indoor sources, including chloroform, 1,4-dichlorobenzene, and formaldehyde. Using a mass-balance model to account for AER and other housing parameters, effective source emission rates (SER) were calculated for each compound. Based on I/O ratios and source emission rates, VOCs could be divided into: (1). indoor-source-influenced compounds, (2). those with contributions from both indoor and outdoor sources, and (3). those with mostly outdoor sources. Significant indoor sources were found for the following six compounds (mean emission rates presented): chloroform (0.11 mg/h), 1,4-dichlorobenzene (19 mg/h), formaldehyde (5 mg/h), acetaldehyde (2 mg/h), benzaldehyde (0.6 mg/h), and hexaldehyde (2 mg/h). Although chloroform had variable I/O ratios across seasons, SERs, which accounted for AER, were similar in both cities for both seasons (e.g., LA means 0.12 and 0.11 mg/h in winter and fall, respectively). Formaldehyde had substantially higher indoor emission rates in the summer in NYC compared to winter (3.8 vs. 1.6 mg/h) but lower in the fall in LA compared to winter (4.3 vs. 5.0 mg/h). Uncertainty analysis determined that source strength calculations were not sensitive to measurement error for a subset of homes in LA.

Adolescent↗

Hearing the voice of the community above the din of the city: New York City Turning Point.

The New York City Public Health Partnership came together to guide the Turning Point Initiative and to involve communities in activities related to improving the health of the city's residents. Early decisions of the Partnership led to the convening of community forums, development of borough planning committees, and creation and implementation of a public health agenda--all of which have fostered community input and participation. Four years later, the Partnership continues to build upon lessons learned and explore ways of ensuring that community voice is incorporated into New York City's public health improvement efforts.

Community Health Planning↗

Clinical experiences in Sakai City Hospital during the massive outbreak of enterohemorrhagic Escherichia coli O157 infections in Sakai City, 1996.

In the middle of July, 1996, a massive outbreak of hemorrhagic colitis (HC) occurred among elementary schoolchildren in Sakai city. This is the most widespread outbreak of O157 infection ever experienced to our knowledge. Lunch foods supplied in the elementary schools in Sakai were contaminated by Escherichia coli (E. coli) O157. One hundred and twenty-one cases developed hemolytic uremic syndrome (HUS) from 12,680 symptomatic patients, including putative secondary infections, and three girls died during this outbreak. Sakai City Hospital is one of the core medical facilities in this community; hence, 425 children with HC were treated at the hospital. Antibiotics were used extensively on all patients. Among them, 12 children developed HUS. All 425 children, including the patients with HUS, recovered without significant sequelae. In the present paper, the clinical experiences during this massive outbreak of E. coli O157 infection in Sakai City Hospital are described.

Anti-Bacterial Agents↗