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At least 37 records · Page 2Linked to original sources
PubMed2005

In vitro activity of VEGF-E produced by orf virus strains isolated from classical and severe persistent contagious ecthyma.

Proliferative orf virus infections in adult sheep have increased in Italy in the past few years: these extreme cases are frequently fatal and difficult to differentiate from other infectious diseases of sheep such as blue tongue. A probable explanation for the proliferative and highly vascularized nature of the lesions was found in the expression of the VEGF-E gene encoded by the orf virus. To investigate a possible role of the viral VEGF in the pathogenesis of severe persistent orf virus lesions, the activity of four VEGF-E variants was compared by an angiogenesis in vitro model. Similar angiogenic activity was found between strains isolated from the classical and the proliferative forms of the disease, even if the latter was able to develop a higher number of vessels during the first 24 h of infection. Our in vitro findings seems to exclude that the VEGF variants encoded by the strain isolated from the atypical form of the disease could be the responsible for the histopathological aspect of the proliferative lesions.

Analysis of Variance↗
PubMed1999

Ehrlichia (Cytoecetes) phagocytophila predisposes to severe contagious ecthyma (Orf ) in lambs.

Eight lambs experimentally infected with Ehrlichia (Cytoecetes) phagocytophila 7 days before exposure to orf virus were compared with control lambs infected with orf virus alone. The dually infected animals differed from the controls in showing skin lesions of greater severity, prolonged viral shedding, and lower antibody titres. Infection with E. phagocytophila had no significant effect on virus-specific lymphocyte proliferation. Such proliferation was detected in the peripheral blood of all lambs as early as 7 days after exposure to orf virus.

Animals↗
PubMed1997

Severe long-lasting contagious ecthyma infection in a goat's kid.

In this report we describe an unusual orf infection in a goat's kid, which lasted for 6 months. The disease was reproduced in two susceptible goat kids, which both completely recovered within 37 days. Further clinical observations on these kids for 12 months did not reveal any signs of orf disease. The orf virus was isolated and identified from the animals which were involved in the original outbreak, from the kid that showed the long-lasting disease and from the experimentally-infected kids. The situation is discussed.

Animals↗