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PubMedDate not supplied

[Hemorrhagic disease of the newborn].

The authors present 16 patients with the idiopathic forms of hemorrhagic disease in newborns, none of which, after birth, having prophylactically received K-vitamin. Seven of them had an early form, four a classical form, and five a late form of hemorrhagic disease. All of them were born at term, four were female and 12 male newborns. The diagnosis was established on the basis of the decreased prothrombin time (PV) and the activated partial thromboplastin time (APTV), as well as their normalization following the applied therapy. The PV values in these patients ranged from 0.009 to 0.65 and the APTV from 33 to 120. The authors point out the significance of the prophylaxis of hemorrhagic diseases in the newborn and the still inconclusive state of scientific dilemmas and clinical practice in this connection.

Female↗
PubMed1994

Hemothorax due to hemorrhagic disease of the newborn.

A three day old male, term infant with hemothorax due to hemorrhagic disease of the newborn was treated successfully with vitamin K and thoracocentesis. Exclusive breast feeding and absence of vitamin K prophylaxis were important diagnostic clues, although hemothorax as a sole manifestation of hemorrhagic disease of the newborn is rare. This case highlighted the good prognosis of an uncommon complication when prompt diagnosis and appropriate treatment are instituted. The importance of vitamin K prophylaxis to all newborns is emphasized.

Drainage↗
PubMed2006

Intracerebral hemorrhage due to hemorrhagic disease of the newborn and failure to administer vitamin K at birth.

In infants, intracerebral hemorrhage (ICH) is most likely the result of trauma or disturbances of coagulation function. Routine and standard care of the newborn includes the administration of vitamin K to prevent hemorrhagic disease of the newborn. We present two infants, the products of home deliveries, who did not receive vitamin K at birth. Both infants developed ICH at 5 weeks of age and presented with signs and symptoms of increased IC pressure. In both cases, recombinant factor VIIa was administered to correct coagulation function and allow immediate surgical intervention which included craniotomy and hematoma evacuation in one patient and placement of a ventriculostomy in the other to treat increased IC pressure. Despite this therapy, both infants were left with severe neurologic sequelae. These two cases illustrate that hemorrhagic disease of the newborn can occur when prophylactic vitamin K is not administered and that it can have devastating consequences. Given these issues, the routine administration of vitamin K to all infants is mandatory and should not be considered optional.

Antifibrinolytic Agents↗