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Neural correlates of naming actions and of naming spatial relations.

Ina [(15)O] water PET experiment, 10 normal subjects retrieved words denoting actions (performed with or without an implement), and another 10 normal subjects retrieved words denoting the spatial relations between objects. Our objective was to test the following hypothesis: that the salient neural activity associated with naming actions and spatial relations occurs in left frontal operculum and left parietal association cortices, but not in the left inferotemporal cortices (IT) or in the right parietal association cortices. There were two control tasks, one requiring a decision on the orientation of unknown faces (a standard control task in our laboratory) and another requiring the retrieval of words denoting the concrete entities used in the action and spatial relations tasks. In accordance with the hypothesis, both naming actions and spatial relations (using the face orientation task as control activated the left frontal operculum; naming actions also activated the left parietal lobe. However, sectors of the left posterior IT were also engaged in both naming actions and spatial relations. When the naming of concrete entities was subtracted from the naming of actions performed with such entities, area MT in the posterior temporo-occipital region was activated bilaterally. On the other hand, when naming of the concrete entities was subtracted from the naming of spatial relations, left parietal activation was found, and when two tasks of naming spatial relations were contrasted to each other bilateral parietal activation was seen, right when abstract stimuli were used and left when concrete objects were used. The activity in posterior IT is thought to be related to object processing and possibly name retrieval at a subconscious level.

Adult↗

Confrontation naming after anterior temporal lobectomy is related to age of acquisition of the object names.

Decline in visual confrontation naming ability may occur as a postacute complication of left anterior temporal lobectomy (ATL) for the treatment of intractable mesial temporal lobe epilepsy. In this study of 26 left ATL patients who demonstrated postsurgery decline on a standardized naming measure, it was hypothesized that naming performance would be significantly associated with specific attributes of the object names. We investigated the relation between performance on the Boston Naming Test (BNT) and the following attributes of the test items: living versus nonliving category (L/NL), word length (WL), written word frequency (WF), and age of acquisition (AoA). Regression analyses revealed that AoA and WF were significant predictors of preoperative group performance. AoA was the only significant predictor of performance after left ATL. For the 17 individuals who demonstrated a statistically meaningful decline on the BNT, as indicated by a Reliable Change Index, individual logistic regressions demonstrated that AoA was the strongest and most consistent predictor of postoperative success/failure for items that had been named correctly preoperatively. Consistent with the literature on naming errors in elderly normals and patients with aphasia or semantic dementia, the results provide evidence that object names learned in late childhood are among the most vulnerable when there is a decline in object naming ability. Investigation of additional attributes and semantic knowledge for the concepts represented by the pictured objects will be necessary to determine whether the naming deficit associated with TLE and ATL reflects an impairment of phonological word-form retrieval, semantics, or both.

Adult↗

Effect of name agreement on prefrontal activity during overt and covert picture naming.

In recent neuroimaging studies, various tasks have been used to examine prefrontal cortex involvement in semantic retrieval and selection. One such task, picture naming, has yielded inconsistent results across studies. One potential explanation for this inconsistency is that the magnitude of prefrontal activity during picture naming depends on the extent to which a given picture evokes a single reliable meaning. To test this hypothesis, fMRI activity in the prefrontal cortex was measured while subjects named pictures with either high or low name agreement. In Experiment 1, subjects named black-and-white line drawings, either covertly or overtly. Across both modalities, we found more left inferior frontal gyrus (LIFG) activity when the subjects named low-agreement pictures than when they named high-agreement pictures. No significant difference in head movement was detected between the two modalities. In Experiment 2, we replicated the effect of name agreement on LIFG activity during picture naming, using black-and-white photographs. These results provide further support for the idea that the LIFG mediates selection among competing alternatives and suggest a means for understanding the naming deficits observed in nonfluent aphasia.

Adolescent↗

Structural alterations in the heart after long-term L-NAME and D-NAME treatment.

N(G)-nitro-D-arginine methyl ester (D-NAME), considered as an inactive enantiomer of NAME, is generally used as a negative control for NO synthase inhibition with L-NAME. The aim of this work was to compare the effect of L-NAME (20 and 40 mg/kg/day), and D-NAME (40 mg/kg/day) on hemodynamic and structural parameters in the rat cardiovascular system. After 4 weeks of treatment, blood pressure and left ventricle weight/body weight ratio increased significantly in all studied groups versus control. Myocardial fibrosis (in %) represented 0.94 +/- 0.04 in control, 4.70 +/- 0.39 in L-NAME (20 mg/kg/day), 10.54 +/- 0.91 in L-NAME (40 mg/kg/day) and 5.25 +/- 0.46 in D-NAME (40 mg/kg/day) group. We conclude that in a long-term experiment D-NAME provokes similar changes in cardiovascular system like L-NAME.

Animals↗

[Adjectives in international anatomical names and the corresponding words in Japanese anatomical names].

International anatomical names are expressed in Latin. In these names some adjectives denote anatomical names that consist of plural words, as deltoidea in Tuberositas deltoidea denotes Musculus deltoideus. We examined the words the correspond to such adjectives in Japanese anatomical names of the structures in the cranial and facial bones, and classified them into following groups: 1) adequate Japanese anatomical names, 2) original meanings of adjectives, 3) the word that is translated freely but lacks the letter corresponding a noun in Latin anatomical name, 4) Japanese anatomical names that correspond different Latin anatomical names, 5) Japanese anatomical names that correspond Latin anatomical names in the past.

Anatomy↗

Ageing and lexical access to common and proper names in picture naming.

The question of whether lexical access for proper names is more impaired by ageing than lexical acess for other words is controversial. The aim of the present investigation was to evaluate the effect of age on proper and common name retrieval in long-term memory. The word retrieval paradigm used to achieve this goal consisted of the naming of photographs representing celebrities (production of a certain kind of proper names: names of people) and objects (production of common names). Compared with younger adults, elderly people experienced more tip-of-the-tongue states for proper names, but not for common names. Thus, the present study provides support for disproportionate age-related problems in lexical access to proper names. This finding is interpreted with reference to the cognitive model of speech production proposed by Burke et al. (1991).

Adolescent↗

What's in a name: Children's knowledge about the letters in their own names.

Two studies were performed to determine whether children's experiences with their own names boost their knowledge about the components of the name, the letters. The children in Study One showed a significant superiority for the initial letter of their own first name in tests of letter-name, but not letter-sound, knowledge. This pattern was found for Australian first graders (mean age 5 years, 5 months), U.S. kindergartners (mean age 5 years, 8 months), and U.S. preschoolers (mean age 4 years, 10 months). Study Two, with U.S. preschoolers (mean age 4 years, 11 months), again revealed an advantage for the initial letter of a child's first name in knowledge of letter names but not knowledge of letter sounds. Moreover, the children were better at printing the initial letter of their own first name than other letters. The results show that different factors are involved in the learning of letter names and letter sounds. They further suggest that children use letter-based strategies with their own names at a time when they are often considered to be "logographic" readers.

Child↗

Proper name anomia and anomia for the names of people: functionally dissociable impairments?

This paper reviews the performance of 10 previously reported patients who have deficits in recalling the names of people, but whose performance in recalling common names is relatively well preserved. An analysis of face naming ability in these 10 patients reveals that the proportion of faces that a patient can name is closely related to whether or not the patient has a retrieval problem that also extends to the recall of other types of proper names such as the names of towns. This analysis suggests that names of faces are particularly difficult to recall relative to other types of proper names, and provides no support for the view that a specialised brain mechanism is involved in the retrieval of people's names.

Anomia↗

Testing the generality of the name letter effect: name initials and everyday attitudes.

The name letter effect is the tendency to evaluate alphabetical letters in one's name, especially initials, particularly favorably. Recent evidence suggests that name initials may even predict career choices. The authors investigated whether people possess favorable attitudes toward basic attitude objects beginning with name initials, both between individuals (e.g., does Judy like jam more than does Doug?) and within individuals (e.g., does Judy like jam more than honey?). Ratings of animals, foods, leisure activities (Studies 1-4) and national groups (Studies 2-4) revealed no object preference as a function of matching name initials. However, the name letter effect emerged (Studies 3-4), as did a clear preference for brand names starting with one's name initials (Study 4). Self-esteem, narcissism, and stimuli characteristics did not reliably influence these effects. Implications for extending name letter effects to basic attitude processes are discussed.

Adult↗

Comparison of the efficacy of two name-learning techniques: expanding rehearsal and name-face imagery.

Two name-learning techniques were compared: expanding rehearsal and name-face imagery. Participants studied name-face associations and were given a cued recall test in which they were presented with a face and were to recall the name. They were presented with either an expanding rehearsal schedule (expanding condition), a distinctive facial feature coupled with a word phonologically similar to the last name and an interactive image linking the name and facial feature (name-face imagery condition), or a no memory (control) strategy. The expanding rehearsal schedule led to superior name learning relative to the name-face imagery and control conditions after a 15-min (Experiment 1) or 48-hr (Experiment 2) retention interval. In Experiment 3, the retrieval practice explanation was tested but not supported; we argue that an encoding variability interpretation is consistent with the overall pattern of results. Applied implications are also discussed.

Association Learning↗

Identification of related gene/protein names based on an HMM of name variations.

Gene and protein names follow few, if any, true naming conventions and are subject to great variation in different occurrences of the same name. This gives rise to two important problems in natural language processing. First, can one locate the names of genes or proteins in free text, and second, can one determine when two names denote the same gene or protein? The first of these problems is a special case of the problem of named entity recognition, while the second is a special case of the problem of automatic term recognition (ATR). We study the second problem, that of gene or protein name variation. Here we describe a system which, given a query gene or protein name, identifies related gene or protein names in a large list. The system is based on a dynamic programming algorithm for sequence alignment in which the mutation matrix is allowed to vary under the control of a fully trainable hidden Markov model.

Algorithms↗

Naming actions and objects: cortical dynamics in healthy adults and in an anomic patient with a dissociation in action/object naming.

Neuropsychological studies have demonstrated that the production of nouns and verbs can be dissociated in aphasia. These reports have been taken as evidence for separate representations of nouns and verbs in the human brain. We used whole-head magnetoencephalography to record cortical dynamics of action and object naming in 10 healthy adults and in 1 anomic patient with superior naming of verbs compared with nouns due to a left posterior parietal lesion. A single set of 100 line drawings was used for both action and object naming. In normal subjects, the activation sequences in action and object naming were essentially identical, advancing from the occipital to posterior temporoparietal and further to the left frontal cortex, without consistent involvement of the classical left inferior frontal (Broca) and temporal (Wernicke) language areas. In the anomic patient, pronounced differences between action and object naming emerged in the left hemisphere. The activation sequence was disrupted at the level of the damaged parietal cortex and did not reach the left frontal cortex even in the relatively easier action naming. The more severely impaired object naming was associated with exceptionally strong and early activation of the left inferior frontal cortex (Broca) and subsequent pronounced activation of the left middle temporal cortex, silent in action naming. Verb and noun retrieval thus utilized a spatiotemporally similar neuronal network in healthy individuals. A clear dissociation in cortical correlates of verb and noun retrieval only became evident in our anomic patient, in whom damage to the language network has resulted in disproportionately worse performance in object than action naming.

Adult↗

Trade names and generic names. Problems for prescribing physicians.

Drugs are marketed with generic and trade names. Our purpose was to study whether this dual name system causes problems to physicians. We interviewed 102 Finnish physicians to find out how well they recalled the composition of combination drugs, and connected the corresponding generic and trade names. The generic name of the given trade-names were known on average by 83% of the physicians who had recently prescribed them, but knowledge of the combination drugs was poor. When generic names were given, on average 9% of the physicians who had prescribed them could mention the corresponding trade names. A multitude of names causes information problems, with possible clinical consequences. From the information point of view, one naming system would be desirable.

Drug Combinations↗

Is action naming better preserved (than object naming) in Alzheimer's disease and why should we ask?

The present study compared object and action naming in patients with Alzheimer's dementia. We tested the hypothesis put forward in (some) previous studies that in Alzheimer's dementia the production of verbs, that is required in action naming, is better preserved than the production of nouns, that is required in object naming. The possible reason for the dissociation is that verbs are supported predominantly by frontal brain structures that may remain relatively better preserved in early Alzheimer's disease. Objects, on the other hand, are supported by temporal lobe structures that are affected early in the disease. An alternative hypothesis, which is supported by other studies, is that action naming is more impaired than object naming due to verbs being semantically more complex than nouns. In order to test these contrasting hypotheses, the present study used more stringent methodology than previous studies. We used a larger set of stimuli with carefully matched object and action items and we collected not only accuracy data but also naming latencies, a measure that is sensitive to even mild lexical retrieval problems. We compared the performance of 19 patients with mild to moderate Alzheimer's disease with that of 19 healthy age matched participants. We found that both the patients and the comparison group responded faster and made fewer errors on the object pictures than the action pictures. A qualitative analysis of the naming errors indicated that object and action naming pose different demands for the language system. The results overall suggest that the patients' performance is an exaggeration of the pattern present in the comparison participants.

Aged↗

Electrophysiological correlates of forming memories for faces, names, and face-name associations.

The ability to put a name to a face is a vital aspect of human interaction, but many people find this extremely difficult, especially after being introduced to someone for the first time. Creating enduring associations between arbitrary stimuli in this manner is also a prime example of what patients with amnesia find most difficult. To help develop a better understanding of this type of memory, we sought to obtain measures of the neural events responsible for successfully forming a new face-name association. We used event-related potentials (ERPs) extracted from high-density scalp EEG recordings in order to compare (1) memory for faces, (2) memory for names, and (3) memory for face-name associations. Each visual face appeared simultaneously with a unique spoken name. Signals observed 200-800 ms after the onset of face-name pairs predicted subsequent memory for faces, names, or face-name associations. Difference potentials observed as a function of subsequent memory performance were not identical for these three memory tests, nor were potentials predicting associative memory equivalent to the sum of potentials predicting item memory, suggesting that different neural events at the time of encoding are relevant for these distinct aspects of remembering people.

Adolescent↗

He can tell which master craftsman blew a Venetian vase, but he can not name the Pope: a patient with a selective difficulty in naming faces.

A patient with damage to the left fronto-temporal region could not name faces, although his recognition and semantic knowledge of people were found to be intact. At variance with described anomics for persons' names, this patient was able to retrieve on definition names of people whose faces he could not name. When, instead, objects were to be named with a person's name, as in the case of manufacturers of Murano glass, the patient, a Murano glass master, was perfect. That is, he could tell which master craftsman in the famous Venini glass-works in Venice had blown a vase, but he could not identify the Pope from a picture. Naming faces is therefore shown to be independent of naming objects.

Humans↗

Picture naming in 3- to 8-year-old French children: methodological considerations for name agreement.

Picture naming has become an important experimental paradigm in cognitive psychology. Young children are more variable than adults in their naming responses and less likely to know the object or its name. A consequence is that the interpretation of the two classical measures used by Snodgrass and Vanderwart (1980) for scoring name agreement in adults (the percentage of agreement, based on modal name, and the H statistic, based on alternative names) will differ because of the high rate of "don't know object" responses, common in young children, relative to the low rate of "don't know object" responses more characteristic of adults. The present study focused on this methodological issue in young French children (3-8 years old), using a set of 145 Snodgrass-Vanderwart pictures. Our results indicate that the percentage of agreement based on the expected name is a better measure of picture-naming performance than are the commonly used measures. The norms may be downloaded from www.psychonomic.org/archive.

Child↗

Inhibitory effects during object name retrieval: the effect of interval between prime and target on picture naming responses.

Three picture naming experiments are reported which examine the relationship between the apparent inhibition of a response on one trial, and naming latency on the subsequent trial. The design of each experiment involves the presentation of prime and target pairs, either presented in succession (Lag 1 condition), or separated by two intervening unrelated trials (Lag 3 condition). A control condition is also included. In Experiment 1, a speeded picture naming task is used, and naming errors are analysed. Target pictures are misnamed at above chance rates with the name of the semantically related prime picture in the Lag 3 condition. In contrast, these prime-related errors do not occur in the Lag 1 condition, suggesting a brief inhibitory effect. If primes are briefly inhibited, then target naming latencies immediately following a related prime should be quicker than target latencies in the Lag 3 condition. Experiment 2 confirms this pattern of results, using exactly the same stimuli and design, but standard naming instructions. Experiment 3 examines whether the inferred inhibition is the result of a self-inhibitory mechanism, using a repetition priming paradigm. If Lag 1 prime representations are self-inhibited, then facilitatory effects from prime/target repetition should be stronger in the Lag 3 condition, than in the Lag 1 condition. The data from Expt 3 were not consistent with this prediction. Taken together, the results of the three experiments suggest that a brief inhibitory effect occurs after retrieval of an object name, and that the inhibition may be accomplished by mechanisms other than self-inhibition.

Adolescent↗