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At least 37 records · Page 2Linked to original sources
PubMed1986

Contrast sensitivity versus visual acuity in retinal disease.

A large group of individuals with retinal disease were tested prospectively for contrast sensitivity by means of Arden gratings. A subgroup of 19 were also tested with the Nicolet automated television system. Individuals with macular or peripheral dystrophy showed a general reduction in contrast sensitivity as visual acuity decreased. The loss of contrast sensitivity was more prominent for high spatial frequencies (6.4 cycles per degree) than for low ones (0.2 cycles per degree). Similar results were obtained for patients with achromatopsia and congenital stationary night blindness. Patients with functional complaints, but no organic basis for decreased acuity, showed greater scatter in their test scores. The Nicolet results showed somewhat smoother curves, but were no more specific in separating normality from abnormality. Contrast sensitivity testing was not specific for the retinal disease entities considered, but may be useful in recording a degree of retinal damage and a degree of functional visual disability. Contrast sensitivity appeared to be reduced whenever acuity was reduced, so that a distinction could be made between patients having a loss of contrast beyond the expectations for their level of acuity and those in whom a loss of contrast simply corroborates the reduction of acuity.

Adolescent↗
PubMedDate not supplied

Incidence of retinal disease following refractive surgery in 9,239 eyes.

PURPOSE: To analyze the appearance, incidence, and characteristics of retinal diseases in myopic patients after refractive surgery. METHODS: We studied retinal disease observed in 9,239 consecutive eyes (5,099 patients) after refractive surgery. Photorefractive keratectomy (PRK) was used to correct myopia in 5,936 eyes (3,184 patients, mean age 30.5 +/- 8.9 years); mean spherical equivalent refraction was -4.71 +/- 2.80 D. Laser in situ keratomileusis (LASIK) was used to correct myopia in 3,009 eyes (1,734 patients, mean age 32.0 +/- 7.8 years); mean spherical equivalent refraction was -13.5 +/- 3.30 D. An anterior chamber phakic intraocular lens (PIOL) was implanted to correct myopia in 294 eyes (181 patients, mean age 32.6 +/- 7.3 yr) with a mean spherical equivalent refraction of -18.5 +/- 5.00 D. RESULTS: Retinal detachment occurred at a mean 53.6 +/- 41.4 months after PRK in 9 eyes (0.15%), 24.6 +/- 20.4 months after LASIK in 11 eyes (0.36%), and 20.5 +/- 17.4 months after anterior chamber PIOL implantation in 12 eyes (4.08%). Choroidal neovascularization occurred a mean 26 months after PRK in 1 eye (0.01%), mean 30.2 +/- 19.3 months after LASIK in 10 eyes (0.33%), and mean 49.0 +/- 33.5 months after PACL implantation in 7 eyes (2.38%). One patient developed a macular hole 12 months after LASIK and another patient developed a macular hemorrhage immediately after LASIK. Epiretinal membrane appeared in one patient 19 months after anterior chamber PIOL implantation. CONCLUSION: There was no relationship between PRK for myopia and retinal disease. LASIK for correction of myopia was followed by a low incidence of retinal disease; additional study is necessary to assess the true impact of the suction ring in the myopic eye. Implantation of an anterior chamber PIOL to correct high myopia was followed by a low incidence of choroidal neovascularization, a high incidence of retinal detachment, similar to other intraocular interventions in highly myopic patients.

Adult↗
PubMed1993

New ophthalmic lasers for the evaluation and treatment of retinal disease.

Ophthalmic lasers are used as diagnostic as well as therapeutic modalities in patients with retinal diseases. Recent advances in laser technology have allowed more convenient selection of wavelength and a wide variety of delivery systems is available to deliver the laser energy to the retina. In addition, newer lasers that disrupt and cut tissue will become available for use in patients with retinal diseases. The use of imaging lasers and lasers in combination with dyes selectively to enhance their effects have become useful in diagnosis and understanding of pathophysiology of diseases. These lasers will also be therapeutically useful. This manuscript delineates the new types of diagnostic and therapeutic lasers, new imaging dyes and techniques as they apply to retinal diseases as well as the principles of laser-tissue interaction as applied to the retina. This should allow the ophthalmologist who treats patients with retinal diseases to make more intelligent decisions regarding the use and acquisition of laser systems.

Animals↗
PubMed2004

Optical coherence tomography to detect and manage retinal disease and glaucoma.

PURPOSE: To review basic principles of optical coherence tomography, and to describe its use in the diagnosis and management of retinal diseases and glaucoma. DESIGN: Perspective. METHODS: Literature review. RESULTS: Optical coherence tomography is a noninvasive imaging technique that has been used increasingly to diagnose and manage a variety of retinal diseases and glaucoma. Optical coherence tomography (OCT) is based on the principal of Michelson interferometry. Interference patterns produced by low coherence light reflected from retinal tissues and a reference mirror are processed into an "A-scan" signal. Multiple A-scan signals are aligned to produce a two-dimensional image that can be thought of as a form of "in vivo histology." Optical coherence tomography has been used to identify macular holes, to differentiate macular holes from simulating lesions, to identify lamellar macular holes, macular cysts, vitreomacular traction, subretinal fluid, pigment epithelial detachment, and choroidal neovascularization. It can be used to identify and quantify macular edema, and to measure retinal thickness changes in response to therapy. Macular thickness measurements determined by OCT correlate well with visual acuity and with leakage observed by fluorescein angiography. Optical coherence tomography is an accurate and reproducible method to measure retinal nerve fiber layer thickness. Particularly, when used in combination with other optic nerve imaging techniques, it can be used to differentiate glaucomatous eyes from normal eyes. Despite its usefulness, OCT has its limitations. Optical coherence tomography equipment is expensive, and not all insurance companies reimburse this procedure. Image quality is dependent on operator technique and can be degraded in the presence of media opacity. Change analysis software for glaucoma applications is not fully developed, and there is a scarcity of age, gender, and race-specific normative data upon which to compare eyes with retinal disease and glaucoma. In the next few years, it is likely that the role of OCT as a method to diagnose and manage retinal disease and glaucoma will be further defined, and many of the current limitations will be overcome. CONCLUSIONS: Optical coherence tomography is a useful imaging technique to diagnose and manage a variety of retinal diseases and glaucoma. Care is needed to avoid artifacts and image misinterpretation.

Diagnostic Techniques, Ophthalmological↗
PubMed2002

Mutated alleles of the rod and cone Na-Ca+K-exchanger genes in patients with retinal diseases.

PURPOSE: To study the possible involvement of the rod (SLC24A1) and cone (SLC24A2) Na-Ca+K exchanger (NCKX) genes in retinal diseases. METHODS: DNA was collected from unrelated patients with retinal disease, mainly from North America. A human genomic library was screened with the cone NCKX cDNA, and hybridizing clones were sequenced to determine the genomic organization of the SLC24A2 gene. The single-strand conformation polymorphism (SSCP) technique and direct sequencing were used to screen the patients' DNA for mutations in SLC24A1 and SLC24A2. The effect of selected missense changes on protein function was tested by measuring potassium-dependent Na-Ca exchange of the mutant proteins expressed in insect cells. RESULTS: Twenty-seven novel sequence changes were found in the rod NCKX gene, 21 of which are unlikely to be pathogenic, because they did not cosegregate with the disease or did not affect conserved regions of the protein. Of the remaining six, two were frameshift mutations found in one patient each. If translated, these alleles would encode nonfunctional proteins. Three of the six possibly pathogenic mutations were missense changes located in conserved regions, and their protein functions were assayed. Only one (Ile992Thr) had a significantly low level of exchanger function, but it was found in two unrelated patients who were heterozygotes with different retinal diseases, and this mutation could not be unequivocally associated with either disease. The last of the six changes is likely to create a new splice acceptor site. The genomic organization of the cone NCKX gene was determined, and it contained 11 exons with a few splice variants. Fifteen novel sequence changes were identified in the cone exchanger gene in patients with a cone dysfunction or degeneration. Only three of these sequence changes, all missense changes found in heterozygous patients, were considered possibly pathogenic. Functional analysis showed only a slight reduction in the activity of the corresponding mutant proteins. CONCLUSIONS: Although variant alleles of the rod and cone NCKX genes were found, none could be definitively associated with a specific retinal disease. The human phenotype associated with mutant exchanger alleles remains unknown.

Alleles↗
PubMed1997

[Immunohistochemical study on vitrectomy specimens of proliferative retinal diseases].

OBJECTIVE: To evaluate the characteristics of cellular proliferation in different retinal diseases. METHODS: Three specific antibodies [to cytokeratin (CK), glial fibrillary acidic protein (GFAP) and actin, respectively] were used. Vitrectomy specimens from 28 cases with different proliferative retinal diseases were studied immunohistochemically. RESULTS: In the vitreous with proliferative vetreoretinopathy (PVR), most of the proliferative cells were derived from glial and retinal pigment epithelial (RPE) cells. In the vitreous of proliferative diabetic retinopathy (PDR), RPE cells might enhance the contraction of proliferative membranes. Increase in actin in firovascular membranes with PDR may play a positive role on the pericytes dropping out from microvessels. CONCLUSION: The cell proliferation in the vitreous associated with the increase of levels of growth factors in pathological vitreous, possibly, is one of the mechanisms for the deterioration of proliferative retinal diseases.

Actins↗