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Clinical application of computer-aided rapid prototyping for tooth transplantation.

The maintenance of healthy periodontal ligament cells in the donor tooth is one of the most important factors for successful tooth transplantation. This is achieved by minimizing the extraoral time during the surgical procedure. If a duplicate form of donor tooth could be obtained before extraction, it would be possible to precontour the recipient alveolar bone compatible with the donor tooth, and thereby reduce the extra-oral time of the donor tooth. We obtained a three-dimensional image with the real dimensions of the donor tooth from a CT Highspeed Advantage, allowing a life-sized resin model of the tooth to be fabricated. From 22 clinical cases, we achieved an average total transplantation time of 7.7 min. The average distance between the transplanted root surface and the alveolar bone from 12 available cases was 0.87 mm at the mesial cervix, 0.91 mm at the mesial apex, 0.98 mm at the distal cervix and 1.16 mm at the distal apex on the postoperative radiographs. Clinical data indicate that computer-aided rapid prototyping may be of value in minimizing the extra-oral time and possible injury to transplanted tooth during the process of autotransplantation.

Adult↗

[Autografts and tooth transplants. Operative indications].

In order to evaluate the prognosis in tooth transplant procedure the literature on this subject was reviewed. The survival of the periodontal ligament is necessary to prevent ankylosis and root resorption. In order to obtain optimal clinical results, the following guidelines are proposed: preparation of the recipient site 2 weeks prior to graft placement, preservation of intact Pdl at time of extraction, rapid reimplantation of tooth in new socket, short term contention (2-3 weeks); endodontic therapy 8-10 weeks after tooth transplantation.

Adolescent↗

Serum and cell-mediated cytotoxicity after primary and secondary orthotopic tooth transplants among RhLA-paired rhesus monkeys.

Twenty-six rhesus monkeys were paired on the basis of RhLA serologically defined (SD) antigens and then mixed lymphocyte cultures (MLCs) were performed for each donor-recipient combination. All but one monkey responded positively to its partner in MLC. In vitro assays for complement-dependent antibody-mediated cytotoxicity (CDC) and lymphocyte-mediated cytotoxicity (LMC) were performed before and after each of two separate orthotopic tooth transplants for each recipient. There was no detectable CDC or LMC before tooth transplantation. The maxillary right central incisors were exchanged between paired monkeys and 60 days later the left maxillary central incisors were transplanted. After the first tooth allograft, there was very little CDC activity in any recipient and only one matched group showed any remarkable LMC activity. However, after the second tooth transplant there was a very clear CDC response in the majority of monkeys. The LMC activity remained low after retransplantation. There did not seem to be any consistent relationship between RhLA match and in vitro cytotoxicity. The results indicate that tooth allografts are weak immunogens but they do evoke humoral immunity after retransplantation. The biological relevance of these serum antibodies remains to be determined.

Animals↗

Experimental autogenous tooth transplantation in the dog: a comparison between one- and two-stage surgical techniques.

Crucial if tooth transplantation is to succeed is preservation of the vitality of the cells of the periodontium and cementum of the tooth graft. Poor contact between the tissues of the recipient site and the root surface when teeth are transplanted to recipient sites prepared immediately prior to transplantation (one-stage technique) could, after transplantation, result in insufficient nutrition to the cells of the root surface and contribute to necrosis of the cells. To improve nutrition, tooth transplantation to recipient beds left to heal for 14 days was performed (two-stage technique). Clinical trials of tooth transplantation by the two-stage technique resulted in a low incidence of tooth graft loss and root resorption. The different results between these two methods, as well as difficulties in evaluating clinical trials, called for an experimental model to be established. In 5 beagle dogs, fully developed autogenous teeth were transplanted using both one-stage and two-stage surgical techniques. The control teeth were transplanted by the one-stage method to recipient beds prepared immediately before transplantation. The test teeth were transplanted using the two-stage method to recipient beds prepared and left to heal for 5 days prior to transplantation. Four pairs of teeth (1 test and 1 control) were transplanted in each dog. One pair of incisors and one pair of premolars were transplanted in the maxilla and in the mandible. Altogether 20 pairs of teeth were included in the study. One pair of teeth fractured during extraction and was therefore excluded from the study. Two pairs of teeth were lost in the first hours after transplantation. Evaluation of the remaining 17 pairs of teeth was made by routine histological examinations after a 6-month period of healing. The blinded examination failed to show a difference between the two surgical methods in terms of frequency of various types of root resorption. The differences between the results after long-term observation of human teeth transplanted by the one- and two-stage tooth transplantation techniques were not found by this experimental model.

Animals↗

Autogenous tooth transplantation: a reevaluation.

This paper discusses whether autogenous tooth transplantation can survive as an option in the future dental armamentaria. Clinically, successful transplants must show a radiolucent space between the roots and surrounding bone. There must be no evidence of ankylosis, no permanent root resorption, and no inflammation. Histologically, the criterion of success is a normal and functional periodontal ligament between the root surfaces of transplants and the bone or gingival connective tissues. Case reports are presented to illustrate replantation or transplantation of teeth. Possible donor teeth are those with the proper amount of viable periodontal ligament, single-rooted teeth, third molars, and malpositioned or impacted teeth. The transplantation procedure involves extraction of the donor tooth, measurement of the root form and amount of periodontal ligament, preservation of donor tooth, preparation of recipient socket, positioning of donor tooth, suturing, and temporary splinting.

Adolescent↗

[Long-term follow-up of tooth transplantation from the functional and periodontal viewpoint].

The outcome of 81 of 99 patients being treated from 1980 to 1993 by transplantation of autologous teeth was investigated. The overall transplant survival rate was 91% after 1 year, 81% after 5 years and 70% after 9 years. The early loss of transplanted teeth was due to healing disorders. The long-term losses were due to caries and replacement resorption. Caries in tooth transplants has to be treated very early, because deep caries or deep drilling leads to an infection of the nutrient canals of the osteodentine. If the pulp chamber of a transplant is once obliterated by osteodentine, endodontic treatment can no longer be performed in many cases. The periodontal condition of the transplants did not differ from that of normal teeth. In 23% there was a decreased tooth mobility, caused by ankylosis of the transplant. 51% of the transplants showed occlusal disturbances but none of the patients had signs of occlusal traumatization of the teeth or of the temporomandibular joint. In comparison to success rates taken from the literature it is pointed out that tooth transplantation has a better long-term prognosis than endodontic treatment. Therefore, in young patients requiring root canal treatment, tooth transplantations should be considered.

Adolescent↗

Autogeneic tooth transplantation in the treatment of malocclusion.

The use of autogenous tooth transplant in selected cases in presented as a solution to the problem case involving congenitally missing, evulsed, or extracted teeth. To insure success, the following requirements should be observed: Donor tooth should have approximately one-half to three-quarters development of final root length. There should be minimal trauma to the root surface of the transplant and to the recipient site. The recipient alveolus should have adequate bone in all dimensions. The time lapse in the transfer from host to recipient site should be minimal. Proper stabilization is assured by suturing of the surrounding soft tissue. Admittedly, the occasion does not commonly arise to utilize either supernumerary teeth or teeth that would ordinarily be discarded. However, the orthodontist and oral surgeon should realize that a unique treatment that can be applied to those uncommon occasions is available.

Adolescent↗

Autogenic tooth transplantation. The "state of the art".

With proper case selection and technique, autogenic tooth transplantation can be a viable treatment modality. The authors present a number of transplant cases and suggest the procedure be considered as an adjunct in orthodontic treatment planning. A comprehensive review of the literature, combined with the authors' opinions and clinical demonstrations, has culminated in a discussion of indications and contraindications, special considerations, optimal timing, technique, and prognosis. It is thought that appropriate utilization can simplify or eliminate prosthetic requirements, reduce the complexity of many orthodontic treatment plans, and convert into routine certain cases heretofore thought to be inoperable.

Alveolectomy↗

[Tooth transplantation].

In the light of the thesis of J. Thibault, the authors suggest, in association with transplantation of wisdom tooth buds into the alveolus of the first molar, a technique consisting of placing the graft in its pre-eruptive position, removing in a block the bud, the gubernaculum and the sub-jacent gingival mucosa. Under these conditions, eruption occurs at the same time as development of the roots, which represents the most physiological solution. At the same time as formation of the root, the authors noted a paradoxal rhizalysis, hypercementosis resulting in ankylosis and conservation of vitality. In addition, almost all the teeth transplanted proved to be highly vulnerable to caries.

Female↗

Tooth transplantation to bone graft in cleft alveolus.

Autotransplantation of teeth has developed from a last resort operation into a well tested and relatively predictable clinical procedure. This article documents four cases where autologous teeth were successfully transplanted into bone from the iliac crest grafted to an alveolar cleft. The possibility of tooth transplantation should be considered when planning dental rehabilitation for patients with cleft.

Adolescent↗

Autogenous free tooth transplantation in man by a 2-stage operation technique. A longitudinal intra-individual radiographic assessment.

Insufficient nutrition to the root surface of autotransplanted mature human teeth after transplantation could be an explanation for the high rates of complications such as root resorption and loss of the tooth transplant. Insufficient nutrition is suggested as being due to the distance between the recipient site tissue and the root surface, and the presence of a blood-clot between the tissues. Improved nutrition could be achieved by transplanting into contact with the vascularised connective tissue of a healing wound. To test this hypothesis, a series of human teeth with fully developed roots were autotransplanted to recipient sites prepared and left to heal for 14 days before transplantation. This study is a follow-up of 57 transplants with a minimum observation time of 1 year. Periodic radiographic examinations of the teeth were performed up to 5 years after transplantation. The results presented, showed a lower incidence of root resorption and extractions than previously reported for teeth with fully developed roots.

Adolescent↗