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PubMed1978

Observation on haematological patterns in pulmonary tuberculosis in Nigerians.

Twenty-one cases of pulmonary tuberculosis seen in the last two years in the chest clinic of the University College Hospital, Ibadan were studied for their haematological patterns at diagnosis and three months after. One group was put on anti-tuberculosis drugs only while the other group was put on anti-tuberculosis drugs and oral iron. The haematological results after 3 months show a significant rise in packed cell volume (PCV) less than 0.01 in the group given oral suppliments. Megaloblastic bone marrow changes occurred in 20 per cent of the patients after 3 months. Seventy-five per cent of the patients had myeloid hyperplasia of the bone marrow at diagnosis and only one of the patients had hypoplastic marrow. It is suggested that oral iron and folate be added to anti-tuberculosis therapy in these patients as part of their management.

Adolescent↗
PubMed1979

[Hospitalisation of patients with pulmonary tuberculosis (author's transl)].

The clinical symptoms of patients with pulmonary tuberculosis, transferred from other hospitals to the Pulmological Center of Vienna, were analyzed. Among 373 transferred patients there were 113 cases (30.3%) of pulmonary tuberculosis. A significant change in the range of symptoms between the examined period (1976/77) and former periods could be shown. By a more accurate regard of the symptoms a primary admission to pulmonary center should be possible in about half the cases and the interval between the primary symptoms and the initial treatment would be shortened in this way. It seems, that tuberculosis of the lung as common sickness only has historical significance, as acute illness of single patient it is still important.

Asthma↗
PubMedDate not supplied

[Spontaneous pneumothorax associated to active pulmonary tuberculosis].

This paper reviewed 8 cases of spontaneous pneumothorax, associated to pulmonary tuberculosis during a period of time of two years at the A.L.M. General Hospital of Toluca, Mex. The diagnosis was confirmed by clinical picture, radiology and bacteriology studies. Six males and two females proceding of the low class; farmers all of them. Their age ranged between 18 and 35 years. Two of the patients showed cavitary lesions, five had difusse fibrosis of the lung. We analized the clinical manifestations and reviewed the pathogenic mechanisms as well the medical and surgical treatment. No deaths ocurred en this series. We concluded that the direct relation between active pulmonary tuberculosis and spontaneous pneumothorax is not clear, but their association in this serie suggested further studies to stablished this. We emphasized the importance of this complication rare in the world literature.

Adolescent↗
PubMed1977

Occurrence with bacteriologically positive pulmonary tuberculosis.

Fever was unchanged by chemotherapy in ten patients with bacteriologically positive pulmonary tuberculosis. Blood cultures were positive for Gram-positive organisms in six patients and for Gram-negative organisms in four patients. The same organism was present in sputa and blood in six patients and in urine and blood in two patients. Leukocytosis was not found, and roentgenographic findings did not suggest superinfection. Nine of the ten patients survived. Blood cultures must be obtained in patients with pulmonary tuberculosis whose fever is not altered by antituberculous chemotherapy, so that concomitant septicemia is not neglected.

Adult↗
PubMedDate not supplied

[Effectiveness of treatment with rifampicin and isoniazid in association with ethambutol or prothionamide in patients with recently detected pulmonary tuberculosis].

In newly discovered patients with cavitary forms of pulmonary tuberculosis treatment with rifampicin, in association with other drugs, leads to recovery (negativation) in 69,6 percent of the patients in 3 months, in 92 per cent after 6 months and in 94,6 percent after 9 months of treatment. Closure of cavities is found in 23,4 percent, 64,5 percent and 76,6 percent of all patients at the corresponding time intervals. Comparisons of the various regimens of chemotherapy which include rifampicin showed that the maximal efficiency was obtained with rifampicin, ioniazid and a third drug (either etambutol or protionamide). The time intervals for the disappearence of bacilli and for the closure of cavities depend to a great extent on the degree of development of the pathological process, on the type of the lesions and the intensity of bacilli elimination at the start of the treatment. The use of rifampicin in new patients, in association with other drugs, leads to a rapid negativation, a shortening of the time necessary for the closure of cavities, especially in patients in whom the disappearence of the bacilli from the sputum occurs in the first three months.

Adult↗
PubMed1977

Incidence of renal amyloidosis in pulmonary tuberculosis.

Incidences of renal amyloidosis were studied in patients who were in various stages of pulmonary tuberculosis and a three year follow-up gave some opportunity to study the effectiveness of anti-tuberculosis treatment on the course of renal amyloidosis. It was concluded that 9 to 11 per cent of all patients with pulmonary tuberculosis will eventually develop proteinuria due to renal amyloidosis after a certain period of time. It has been postulated that once amyloidosis has extensively involved the kidneys, anti-tuberculous treatment will not cause any regression in the course of renal amyloidosis.

Adolescent↗
PubMed1975

[Results of 79 hepatic biopsies in untreated bacillary pleurs pulmonary tuberculosis patients].

The authors report 79 needle biopsies of the liver, using a Menghini needle, carried out as routine in untreated cases of pulmonary tuberculosis with positive sputum. Apart from the histological study, the authors carried out, in 30 cases, a bacteriological study of the liver fragment. The bacteriological and histological results are reported here in detail, then compared with those in the world literature. No significant correlation was found between the histological type of the suggestive hepatic lesions, e.g. follicular appearances or appearances of nodular küpferian hyperplasia and the radioclinical variety of pulmonary tuberculosis, e.g. parenchymatous, pleural or miliary. The authors emphasize the significance of each type of pathological lesion encountered, in particular, the appearance of nodular küpferian hyperplasia or intralobular, lymphohistiocytic islets, which seem to them remarkable by their relative frequency and their chararacter fairly suggestive of tuberculosis. In spite of the low number of pathological appearances obtained in these liver biopsies, the present study nevertheless permitted a few interesting conclusions on the blood spread of the tubercle bacillus and the significance of changes in the Küpfer system during common pulmonary tuberculosis.

Adult↗
PubMed1979

The importance of finger clubbing in pulmonary tuberculosis.

Finger clubbing was observed in 21% of 70 adult Nigerian patients presenting with pulmonary tuberculosis. These patients had a significantly higher incidence of haemoptysis and they also showed a significantly lower body weight and serum albumin than those without clubbing. Their chest x-rays revealed larger cavities and at 2 months the mortality of the patients with finger clubbing (40%) was very much higher than of those without (5.5%). It is suggested that finger clubbing is of value in assessing patients with pulmonary tuberculosis because it helps to identify those with severe destructive disease.

Adult↗
PubMed1979

[Perforation of gastroduodenal ulcers and pulmonary tuberculosis].

17 observations of the perforation of gastroduodenal ulcer in pulmonary tuberculosis cases are analysed. Most of the patients were males, aged over 50, with protracted chronic forms of tuberculosis. In all cases the suturing of perforation was carried out. 9 patients died. The conclusion has been drawn that a massive antibacterial therapy, which should be carried out in specialized medical institutions, is imperiable.

Adult↗
PubMed1979

Pulmonary tuberculosis in childhood. An analysis of 263 cases seen at Ibadan, Nigeria.

The salient features of pulmonary tuberculosis in 263 Nigerian children are presented. Attention is drawn to the little known diagnostic presence of supraclavicular lymphadenopathy which is often accompanied by pulmonary tuberculosis. In the childhood population where early diagnosis of tuberculosis is sometimes difficult and depends mostly on a high index of suspicion, the finding of such a sign is highly significant and useful. Even though phlyctenular kerato-conjunctivitis has been reported to be caused more often by bacterial antigens other than tuberculosis, the experience in this part of the world is that its presence is still almost pathognomonic of tuberculosis. Outpatient ambulatory management though successful was associated with a high default rate. Suggestions are made on ways to reduce this rate.

Adolescent↗
PubMed1979

Immunoprofile studies in patients with pulmonary tuberculosis. II. Correlation of levels of different classes of immunoglobulins and specific antibodies with the extent of tuberculosis.

Humoral immune response of patients with newly detected, bacteriologically confirmed pulmonary tuberculosis was determined prior to initiation of chemotherapy. Correlation with the extent of the disease was studied. A significant rise in the IgA and IgG levels in the serum was observed, the increase in the IgA levels correlated with the extent of the disease. In tuberculous patients elevated levels of anti-OT (ppd) antibodies were found by haemaggluination, but no marked correlation was observed with the extent of the disease. There was no interrelationship between the IgA or IgG increase and that of specific anti-OT (PPD) antibodies. The importance of the mentioned findings is discussed.

Antibodies, Bacterial↗