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At least 433 records · Page 24Linked to original sources
PubMed1992

Soft tissue leiomyosarcoma. A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA content.

BACKGROUND: Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS: Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not included. RESULTS: The annual incidence was 0.13/10(5). The ratio of men to women was 1.2, and the median age was 65 years. The thigh was the most common location. Almost half of the tumors were subcutaneous. The median tumor size was 6 cm (range, 1-25 cm). All patients were treated with surgery, and in 19 cases it was combined with adjuvant radiation therapy or chemotherapy. The cumulative 5-year survival rate was 64%. Multivariate analysis indicated that age of 60 years or greater (relative risk [RR] = 8) and intratumoral vascular invasion (RR = 4) were independent risk factors for death resulting from tumor. DNA aneuploidy (RR = 4) and tumor necrosis (RR = 3) were associated with poor prognosis, but did not reach statistic significance. CONCLUSIONS: Advanced age, vascular invasion, and DNA aneuploidy could be used to identify prognostic subgroups.

Adult↗
PubMed2000

Community-level determinants of child growth in an Indonesian tea plantation.

OBJECTIVES: The paper presents the results of an ecological-economic approach to identifying community-level factors that influence the physical growth of young children. DESIGN: A cross-sectional design was used to obtain both the anthropometry and the ecological-economic data. SETTING: The sites were 24 communities located in a tea plantation near Bandung, West Java, Indonesia. SUBJECTS: 415 children between the ages of 6 and 18 months. METHODS: Epidemiological and ethnographic methods were used to measure community infrastructure and services related to child growth. Anthropometry was used to measure child growth. Econometric methods, including probit and ordinary least squares regression, were used to analyze the effect of community-level factors on child growth. RESULTS: Community vaccination programs, child care services, environmental sanitation and latrines were associated with better child growth. We concluded that community-level goods and services substantially contributed to health in early childhood.

Agriculture↗
PubMed1997

Evolving methods in genetic epidemiology. IV. Approaches to non-Mendelian inheritance.

From this overview it can be concluded that the understanding of the biologic properties and the development of analytic tools to identify repeat sequence mutations, genomic imprinting effects, and mitochondrial mutations are only beginning. Development of approaches to identify such phenomena as modifying effects or genetic components of complex traits is a new area of research. Not mentioned here are the ways in which locating a gene with such properties (i.e., linkage analysis) would be affected if such properties were not accounted for, or how to alter such analyses to obtain full information. Again, this is an exciting new area of research that will continue to motivate epidemiologists and geneticists. Hopefully, we have learned a lesson from the earlier conclusions of the studies on myotonic dystrophy: keep an open mind and never assume that the "geneticist should know best about behavior of genes".

Epidemiologic Methods↗
PubMed1998

New methods in psychiatric epidemiology.

Research on the epidemiology of mental disorders has now reached the stage where it is possible for comparisons to be cautiously made between population samples. This is made possible for the following reasons: recognition that the populations at risk, including their age composition and exclusions, must be clearly specified; the use of the standardized diagnostic criteria in international use (ICD-10 and DSM-IV); and standardized clinical assessments, such as the Schedule for Clinical Assessment in Neuropsychiatry, the Diagnostic Interview Schedule (DIS) or Composite International Diagnostic Interview (CIDI), including the automated CIDI-A, and for the elderly, the Geriatric Mental State Examination and the Canberra Interview for the Elderly. Some recommendations are made for future epidemiological studies, including these advances in methodology. Emphasis is given to the value of using continuous measures of symptoms, in addition to categorical diagnoses. In research on etiology, investigators should make every effort to test innovative hypotheses, particularly where these involve both biological and psychosocial variables.

Adult↗
PubMed2000

Introduction and overview. Statistical methods in genetic epidemiology.

Common terms used in genetics with multiple meanings are explained and a brief overview given of the four major areas of genetic epidemiology--the study of familial aggregation, segregation, cosegregation and association. Familial aggregation measures the potential for a trait to have a genetic aetiology. Segregation analysis uncovers single gene segregation. Cosegregation with genetic markers gives rise to linkage, which is used to locate trait genes on the genome. Association analysis is used for fine mapping, but rests on the assumption that linkage disequilibrium exists.

Chromosome Mapping↗
PubMed2000

[Achievement of causal inference in the social medicine in Japan].

As a condition to achieving an agreement of recognition on the causal relationship in medicine, we firstly explained Hume's problem and counterfactual model. We, however, emphasized that we believe in the existence of causality on medical issues in our daily lives. Therefore, we illustrated conditions when we usually believe in causality. On the other hand, we criticized two well-known key phrases, "lack of mechanism in epidemiology" and "black box in epidemiology", which have often been used in Japan for skeptic viewpoints against epidemiologic methods even if epidemiology is often used to elucidate a causal effect in medicine in the world. We emphasized that a priori determinations of levels for inference of mechanism is necessary. And, the level and feature of mechanism should be defined in concrete expressions. After explanation of these basic concepts, we mentioned a classic view on specific diseases and non-specific diseases which have not been sufficiently discussed enough yet in Japan. As an example, we used the statements in the Japanese Compensation Law for the Health Effect by Environmental Pollution. In Japan, the classification of these diseases has been confused with that between manifestational criteria of diseases and causal criteria of them. We described the basic concepts to illustrate the causal relationship between non-specific disease and its exposure by using attached figures. Actually, we cannot recognize disease occurrence as a specific disease for several reasons. We indicated that we can recognize the magnitude of effect by causal relationships in medicine as a quantitative continuous variable.

Causality↗
PubMedDate not supplied

[Canine visceral leishmaniasis: evaluation of the serologic method used in epidemiologic studies].

A comparative study was made of eluates of the blood of dogs experimentally infected with different trypanosomatids. Using antigens prepared from promastigotes of Leishmania mexicana, L. braziliensis and L. chagasi, assessments were made by the indirect immunofluorescence test. The results showed a sensitivity of 87.5% in the diagnosis of canine visceral leishmaniasis, independent of antigen used. Cross-reactions occurred in 75% of cases of cutaneous leishmaniasis and 83.3% of dogs with chagas' disease. An epidemiological survey in an area of leishmaniasis confirmed that immunofluorescence tests on eluates of dogs' blood give cross-reactions between L. braziliensis and L. chagasi. The results suggest that such testing could be useful in public health campaigns but attention is drawn to the fact that the level of positive reactions cannot be used as an indicator of the prevalence of canine kala-azar.

Animals↗
PubMed1977

Rationale and methods for an epidemiologic study of cancer among Seventh-Day Adventists.

Considerable evidence was found that Adventists are a low-risk population to develop cancer of many sites. Adventists have numerous unique life-style and dietary habits with great variability within the population in adherence to these practices as well as considerable variation in duration of exposure to these characteristics. Thus this study population will likely be extremely productive in identifying dietary habits or other life-style characteristics that are etiologically related to various cancer sites.

California↗