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At least 433 records · Page 24Linked to original sources
PubMed2002

Paying for reproductive health services in Bangladesh: intersections between cost, quality and culture.

In 1997 a consortium of non-governmental organizations (NGOs) in Bangladesh began to implement health sector reform measures intended to expand access to and improve the quality of family planning and other basic health services. The new service delivery model entails higher costs for clients and requires that they take greater initiative. Clients have to travel further to get certain services, and they have to pay more for them than they did under the previous door-to-door family planning model. This paper is based on findings from a qualitative study looking at client and community reactions to the programme changes. It examines a number of barriers to access and constraints to cost recovery, including gender, class and ideas about entitlements, the role of government and obligations among people. The NGOs want to maximize cost recovery while making the basic services they offer accessible to most people. The findings suggest that this requires more than the establishment of an appropriate pricing structure. Attitudes related to charging and paying for services must also change, along with the institutional policies and practices that support them.

Attitude to Health↗
PubMed2004

HIV/AIDS, sexual and reproductive health: intersections and implications for national programmes.

HIV and AIDS have a myriad of effects on sexual and reproductive health and rights, and sexual and reproductive health services are critical for women and men with HIV and AIDS. Yet there has been a dearth of visible, in-depth mainstream attention to the links between sexual and reproductive health and prevention and treatment of HIV/AIDS since the early 1990s among major stakeholders internationally. This paper argues that access to essential sexual and reproductive health care should be provided in HIV/AIDS prevention, care and treatment programmes, and appropriate forms of prevention and treatment of HIV/AIDS should be included in all sexual and reproductive health services as a public health priority, particularly in sex education, family planning and abortion services, pregnancy-related care, sexually transmitted infection (STI) services and services addressing sexual violence. The paper analyzes existing barriers to linking and integrating these services, e.g. at country level due to the traditional training of health workers to implement vertical programmes, separate sources of funding for National AIDS Control Programmes and sexual and reproductive health services, and in international donor programme and UN agency structures. This paper calls for leadership to be exercised by donors, all the UN agencies working together, governments, health service managers and providers, NGOs and advocates in both fields to develop and implement these linkages at country level. Finally, it is crucial that UNAIDS, WHO, UNFPA, UNICEF, the Global Fund to Fight AIDS, TB and Malaria and those working to reach the targets set by the Millennium Development Goals come on board in these efforts.

Cooperative Behavior↗
PubMedDate not supplied

The intersection of adolescent development and intensive intervention: age-related psychosocial correlates of treatment regimens in the diabetes control and complication trial.

OBJECTIVE: To provide evidence relevant to developmentally sensitive intervention and prevention of adolescents' psychosocial distress associated with treatment of type 1 diabetes. METHODS: We used self-reports on the Diabetes Quality of Life and SCL-90-R inventories administered at baseline, 1, and 3 years following adolescents' (n = 224) entry into the Diabetes Control and Complications Trial. RESULTS: Initiation of intensive treatment in early adolescence was associated with increasing school dissatisfaction; initiation in later adolescence resulted in marginal elevations in psychological distress. CONCLUSIONS: Age at entry moderates impact of intensive treatment on reported psychosocial distress. Intervention and prevention efforts sensitive to the interaction of developmental tasks with health treatment goals may optimize the well-being of adolescents with type 1 diabetes.

Adolescent↗
PubMed2002

Sexual harassment between same-sex peers: intersection of mental health, homophobia, and sexual violence in schools.

This article provides a historical and legal framework for defining peer sexual harassment from three different perspectives: sex discrimination, mental health, and sexual violence. Major court decisions that define sexual harassment in both education and the workplace are highlighted, and arguments regarding sexual harassment between peers of the same sex are profiled. This research also identifies sexism and heterosexism as a major social violence problem in U.S. education and argues that peer sexual harassment is sexual violence with considerable mental health implications for both boys and girls. Recommendations for social work practice regarding peer sexual harassment in schools are discussed.

Adolescent↗
PubMed1988

Seatbelt cervical injury in an intersection type vehicular collision.

The seatbelt syndrome represents a spectrum of traumatic entities reported in restrained survivors of sudden impact decelerations, who may exhibit bruising of the torso along the site of seatbelt placement. The case is presented of a patient sustaining cervical spine dislocation and quadriplegia attributed to impingement upon a 3-point attachment harness restraint.

Accidents, Traffic↗
PubMed1993

The intersection of technology and care in the ICU.

In this article the author describes the paradoxical nature of the relationship between technology and care in the ICU. Although technology enhances care by expanding the repertoire of competent nurses' responses to the patient, it simultaneously alienates nurse and patient, hence inhibiting care. This occurs when nurses and patients have different understandings of technology and when the nurse identifies with the values imposed by technology at the expense of acknowledging her own and the patient's vulnerability.

Critical Care↗
PubMed2004

High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease.

PURPOSE OF REVIEW: Low HDL-cholesterol, diabetes mellitus and elevated C-reactive protein as well as various inflammatory diseases are risk factors for coronary heart disease. Both diabetes mellitus and inflammation decrease HDL-cholesterol. We summarize recent findings on the mechanisms underlying low HDL-cholesterol in diabetes and inflammation, as well as on novel functions of HDL that may protect not only from atherosclerosis but also from diabetes mellitus and inflammation-induced organ damage. RECENT FINDINGS: Elevated levels of non-esterified fatty acids and disturbed insulin action contribute to low HDL-cholesterol in diabetes mellitus by modifying lipolysis, apolipoprotein A-I production, as well as the activities of adenosine triphosphate-binding cassette transporter A1 and lipid transfer. Inflammation causes low HDL-cholesterol by increasing the activities of endothelial lipase and soluble phospholipase A2 and by replacing apolipoprotein A-I in HDL with serum amyloid A. HDL and lysosphingolipids therein have been identified as activators of the protein kinase Akt, which in turn is a regulator of apoptosis in beta-cells, endothelial cells, and smooth muscle cells, as well as a regulator of nitric oxide production and adhesion molecule expression in endothelial cells. SUMMARY: The protective properties of HDL in cytokine production, lipid oxidation, cholesterol efflux and reverse cholesterol transport make HDL a protective agent in inflammation-induced organ damage including diabetes mellitus. However, inflammation and diabetes cause a decrease in HDL-cholesterol concentrations and impair HDL function, placing HDL into the centre of a vicious cycle that may escalate into diabetes mellitus, inflammation-induced organ damage and atherosclerosis.

Animals↗
PubMed2003

Borderline patients at the border of treatability: at the intersection of borderline, narcissistic, and antisocial personalities.

The author discusses the difficulties involved in treating patients with borderline personality disorder and concomitant Cluster B-narcissistic, histrionic, and/or antisocial-personality traits or disorders. He presents eight vignettes of patients with borderline personality disorder combined with various types of Cluster B personality traits or disorders and describes the course of their treatment. The author posits that such patients fall on a continuum ranging from difficult to treat but still treatable, to those with strong narcissistic or even psychopathic traits whose illness fails to improve no matter what treatment methods are applied (i.e., they have "untreatable" illness).

Journal Article↗
PubMed2004

Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?

PURPOSE OF REVIEW: To examine connections between triglyceride metabolism and inflammation, especially as they relate to transcriptional regulation through peroxisomal proliferator activated receptors activation. RECENT FINDINGS: Peroxisomal proliferator activated receptors, members of the steroid hormone nuclear receptor family, have been of particular interest as a mechanism through which different dietary components might control gene expression. Extensive prior work has defined the central role peroxisomal proliferator activated receptors play in many key metabolic responses, including glucose control and lipid metabolism. Emerging evidence suggests peroxisomal proliferator activated receptor activation may limit inflammation and atherosclerosis. The demonstration that certain fatty acids can activate peroxisomal proliferator activated receptors belies the potential link between nutritional components and peroxisomal proliferator activated receptor responses. Interest in this connection had been heightened by recent evidence that lipolysis in certain situations can both generate peroxisomal proliferator activated receptor ligands and limit some known inflammatory responses. SUMMARY: Lipolytic peroxisomal proliferator activated receptor activation suggests new ways in which to reconsider triglycerides and the distal consequences of their metabolism, including the possible effects on inflammation and atherosclerosis.

Arteriosclerosis↗
PubMed2006

HIV medication adherence. The intersection of biomedical, behavioral, and social science research and clinical practice.

The unique nature of the HIV/AIDS epidemic and the needs of people living with HIV disease have required the expertise of clinicians and biomedical, clinical, behavioral, and social scientists. The successes achieved in the past 25 years are the collective product of committed individuals from within all these disciplines. This is particularly true in HIV care and therapeutics and, specifically, in medication adherence, where biologic, clinical, behavioral, and social issues converge and each has been critically important in achieving the stunning therapeutic benefit for individuals and populations with HIV disease. There has been growing acceptance and success of interdisciplinary collaboration to address HIV medication adherence in the past 2 decades. Nevertheless, there remain real and perceived impediments obstructing collaboration among biomedical, behavioral, and social scientists and important differences between all these research domains and clinical practice. Differences in training and expertise, perceived mission, orientation, culture, and personal and professional skills can thwart meaningful collaboration or be used synergistically to move understanding and improvement of HIV medication adherence forward. This article explores these relations and differences from the perspective of an HIV clinician and clinical researcher with a background in biology and an inclination toward behavioral and social science and suggests some approaches for their resolution.

Anti-HIV Agents↗
PubMed2026

Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.

Understanding toxin resistance in insects is key to appreciate niche adaptations but remains challenging due to its often-polygenic basis. A well-known example is the specialized association of Drosophila sechellia with noni fruit ( Morinda citrifolia ), which is toxic to most other insects, including the closely-related Drosophila simulans and Drosophila melanogaster . Toxicity of noni is due to its high concentration of octanoic acid (OA), but the mechanisms that determine sensitivity or resistance to OA in different species remain poorly understood. Here, we experimentally-evolved D. simulans with increased OA resistance, identifying multiple loci under selection. Cross-referencing these with a genome-wide, OA-resistance CRISPR screen in a D. melanogaster cell line highlighted two proteins: Kraken, a putative detoxification enzyme expressed in digestive and renal tissues, and Alkbh7, a mitochondrial protein linked to fatty acid metabolism. Both genes show elevated expression in D. sechellia and OA-resistant D. simulans . In D. melanogaster , kraken mutants are more OA-sensitive, while Alkbh7 overexpression increased OA resistance. Importantly, mutation of these genes in D. sechellia reduced OA tolerance. Our identification of genes underlying OA resistance in laboratory and natural contexts demonstrates how complementary, cross-species selection approaches can provide insights into complex mechanisms of toxin susceptibility and adaptation; such methods could also have practical applications in the characterization of natural and artificial insecticides.

Journal Article↗