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At least 433 records · Page 24Linked to original sources
PubMed1988

An on-line microcomputer program for the monitoring of physiological variables during rest and exercise.

This paper describes a microcomputer system for the on-line display of physiological variables such as: lung ventilation, tidal volume, respiratory frequency, oxygen consumption, heart rate, oxygen pulse, respiratory exchange ratio, grams of fat and carbohydrate metabolised, mean skin temperature, rectal temperature and mean body temperature. The program has been written in Pascal. The modular nature of this language facilitates modification of the program to make it compatible with a variety of hardware and peripherals.

Calibration↗
PubMed1988

Stepwise multivariate discriminant analysis (SMDA) for paired and unpaired biomedical data using microcomputers.

It may be necessary in biostatistics to discriminate between individuals and groups. The discriminant analysis is used for this purpose. The discriminant procedure has been programmed for microcomputers. The program has been written in a generic BASIC in order to make the procedure user-friendly. To have such a software package implemented on a personal computer may greatly facilitate the use of this complex analysis in biomedicine.

Computers↗
PubMed1989

An Apple IIE microcomputer program for multiple non-independent comparisons by the Scheffe's test.

When more than two groups of observations from the same set of experimental data are compared and pairwise tested for equality of their means, appropriate statistical treatment of the data is required. The overall variation in the set of data must be considered, and also the statistical non-independence of each pairwise comparison must be taken into account. We describe a simple Apple IIE microcomputer program that applies the Scheffe's test for multiple comparisons. A numerical example and a sample output of this program are also included. The listing of the program is reported in the Appendix.

Analysis of Variance↗
PubMed1989

Microcomputer collection and analysis of RR-interval data in the BB-rat.

An analog to digital converter and microcomputer system for the collection of real-time RR-interval data in the BB-rat is described. Calculation of the statistic R is discussed and a commented program listing in Microsoft basic, for performing this transformation, is included as an appendix.

Action Potentials↗
PubMed1991

A microcomputer-based device to simulate biomechanical environments for cultured cells.

We describe software and hardware for a microcomputer-based cyclic strain device which applies programmed cycles of elongation and relaxation to cultured cells. This system has the potential to simulate many of the complex mechanically active environments found in living systems. As a sample application, we use it to simulate the cyclic stresses to which vascular smooth muscle cells in the arterial system are exposed.

Arteries↗
PubMedDate not supplied

Microcomputer-based analysis of cardiovascular indices.

A microcomputer-based program has been developed which performs rapid and accurate acquisition of cardiovascular data from instrumented animals or isolated perfused hearts with concurrent analysis and display of the hemodynamic indices. The system allows real-time viewing of the data in four alternative graphic displays. These include: (1) a strip-charge type display of all channels; (2) a full screen display of any single channel; (3) display of pressure-segment length; and (4) trend graphs (cumulative change with time) of calculated hemodynamic indices such as heart rate, systolic and diastolic blood pressure, percent change in myocardial segment length, mean blood flow and percent change in arterial diameter. Precise analysis of both transient and steady-state events may be performed on any segment of data stored on the hard disk. The data at any point in the experiment may be accessed by cursoring through any trend graph of the derived indices, by recalling special event markers or by using the automatic time markers. The calculated results are printed and stored in ASCII files which can be transferred to spreadsheets, databases, graphics or statistical programs.

Animals↗
PubMed1993

Using an integrated software package for clinical data analysis on a microcomputer.

An integrated software package was used effectively for entering, organizing and analyzing clinical research data on a microcomputer. Both the database and the spreadsheet components of the package were used in the process. The database component enabled a form to be created for entering the data. The spreadsheet component was used in the organization and analysis of data. Macros were written within the spreadsheet environment for the statistical analysis of data. The purpose of this paper is to illustrate how an integrated software like Symphony could offer features beyond simply the use of a spreadsheet for the analysis of research data. Also highlighted are the other useful features of the integrated software that are not directly related to data analysis.

Adolescent↗
PubMed1980

High-speed automatic analysis of eeg spike and wave activity using an analogue detection and microcomputer plotting system.

Spike and wave activity is detected by analogue circuitry which separately filters the spike and the slow wave components from the EEG. The filter outputs are converted to DC voltages, which are then compared with individually adjusted threshold voltages. A detector output pulse is produced when both the spike and the wave threshold levels are exceeded. A graph of the incidence of spike and wave activity per 15 min intervals over 24 h is plotted by a microcomputer and modified impact printer. The analysis is carried out at 60 times real time on EEG recordings obtained from unrestrained patients using a portable cassette-tape recorder.

Electroencephalography↗
PubMed1980

Microcomputer method for the analysis of spontaneous bursting activity of units in epileptic cat cortex.

Exact probability analysis of the spontaneous bursting activity of epileptic units is a common problem. A microcomputer method, suitable for the calculation of the scalar function of two variables of the spike occurrence of this type of discharge, has been developed. The time measured from the first spike of a burst and the duration of the preceding interburst interval were chosen as the variables of the evaluated functions. A typical unit activity was analysed by the program. The method may be useful for the classification of different bursting patterns.

Animals↗
PubMed1983

Spike detection based on a pattern recognition approach using a microcomputer.

A system for the detection of spikes and sharp waves (SSWs) in EEGs of epileptic patients is described. The system uses a pattern recognition technique and it is implemented in a hybrid microcomputer. It performs the on-line simultaneous analysis of 4 EEG channels and thus it is appropriate for long-term EEG recording. The performance of the system was considered satisfactory when compared with that of a panel of electroencephalographers.

Action Potentials↗
PubMed1987

Microcomputer analysis techniques for evaluation of benzodiazepine effects on rat electrocorticogram.

Quantitative analysis of drug effects on the EEG is usually performed on a minicomputer using an EEG signal that has been recorded on a high frequency FM tape recorder and edited to remove artefact. However, this equipment is expensive and so the present study evaluated a much cheaper system, an 'on-line' microcomputer and 3 programs for data reduction. Using this system to assess diazepam effects on the rat electrocorticogram, it was concluded that period amplitude analysis may be preferable to the Fast Fourier Transform or Hjorth analysis.

Animals↗
PubMed1981

The use of a microcomputer in a biomedical research project.

The use of an inexpensive microcomputer system in an NIH-supported biomedical research project is explained. Computer programs which store and analyze air pollution data; records from hospitals, doctors' offices, pharmacies, and schools; and data from a community public health survey are described. The analysis consists primarily of calculations of various temporal and geographical correlation coefficients in order to determine whether particulate air pollution is affecting public health in southern Puerto Rico.

Air Pollution↗
PubMed1983

A microcomputer record system for diabetic patients.

A computerised medical records system for diabetic patients has been developed on a Vector Graphics MZ microcomputer using programs written in UCSD-Pascal. The system allows addition or deletion of patient records, alteration of records, alphabetical listing of recorded patients' names, and printing of individual records in a concise format. The amount of information capable of being stored in each record makes the easy to use system a useful device in the clinical management of diabetic patients.

Computers↗
PubMedDate not supplied

Steady state enzyme kinetics: experimental design and data analysis by microcomputer.

One of the most time-consuming, yet essential, operations involved in the steady state kinetic study of enzymes is the design and optimization of experimental conditions. A computer program was developed for the Sinclair ZX-81 (or TS-1000, 1500) microcomputer which will optimize substrate concentration for preliminary and subsequently more refined kinetic analysis of one, two or three substrate systems. This program also analyzes the data collected from these studies by linear regression, weighted linear regression or weighted non-linear regression. In addition to the above program several of the enzyme kinetic statistical analysis programs of Cleland (1979) have been translated from FORTRAN into BASIC and implemented on the ZX-81 and the TRS-80 model II. Inexpensive commercially available software was used to overcome the inability of the ZX-81 to read data files from magnetic tape making the data analysis programs easier to use.

Computers↗
PubMedDate not supplied

Exchange of environmental health information between microcomputers.

Programs have been developed which permit the transfer of disk files (programs or data) from a TRS-80, Model-III microcomputer to a TRS-80, Model-I system via an RS-232-C serial interface. The programs allow researchers to effectively use both computers in the entry and processing of air pollution and epidemiological data, in addition to facilitating the exchange of programs, data, and word processor documents between users of the two machines. A detailed explanation is given of how the programs control the RS-232 hardware and use several of the file management routines in each computer's operating system to achieve successful information transfer.

Air Pollutants↗
PubMedDate not supplied

Microcomputer analysis of hyperbolic and non-hyperbolic steady-state kinetics.

A BASIC computer program has been developed which has been used to show that bovine lens aldose reductase with NADPH as substrate follows a 1:1 function, while rabbit lens hexokinase has a rate equation of minimum degree 2:2, and bovine lens polyol dehydrogenase has a rate equation of minimum degree 1:2 with xylitol as substrate. The parameter estimates obtained are very close to those from the BMDP3R curvefitting program on an ICL 2980 mainframe computer, with identical conclusions as to the minimum degree of the rate equation. The computer program can be run on any microcomputer with high resolution graphics in less than 48 K of random access memory.

Aldehyde Reductase↗
PubMed1985

A practical, high-resolution, microcomputer-based method for the analysis of relaxation data exhibiting multicomponent exponential decays.

We have developed and tested a practical, rapid, high-resolution, microcomputer-based method for the analysis of multicomponent exponential decays. The analysis utilizes the Fourier deconvolution technique and includes methods to reduce noise both in the input data and in the results. The developed method is particularly well suited for analysing decays consisting of a wide range of decay times. The method resolves two exponential decays differing by a factor of two when the input data are mathematically generated and without noise, and resolves two decays differing by a factor of three when 2% Gaussian noise is present in the same data. The method lends itself to routine analysis of any relaxation process consisting of exponential decays, including biomedical applications such as enzyme kinetics, circulatory transport functions, pharmacokinetics, plasma exchange therapy, and analysis of compartmental models for any process.

Birefringence↗