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PubMed1970

[Language disorders].

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Central Nervous System Diseases↗
PubMedDate not supplied

Assessing the assessments: a comparison of two clinical pragmatic profiles.

Recent years have seen a growth in interest in pragmatic aspects of communication, and the application of this area to language disorders. This has led to the development of a range of "pragmatic profiles" to assess the disordered language of children and adults. In this study we investigate two such profiles designed for use with aphasic patients. In particular we look at aspects of interscorer reliability (comparing scorers from different linguistic traditions), scoring sensitivity (two- versus five-point scales), and diagnostic accuracy (the ability to differentiate different aphasic syndromes). We conclude that training in scoring these profiles must be uniform, but also that greater sensitivity is needed in the categories available.

Aged↗
PubMed2006

Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations.

OBJECTIVE: A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia. Therefore, the FOXP2 gene could be considered a good candidate gene for the vulnerability to schizophrenia. METHODS: A set of single nucleotide polymorphisms mainly located in the 5' regulatory region of the FOXP2 gene was analysed in a sample of 186 DSM-IV schizophrenic patients with auditory hallucinations and in 160 healthy controls. RESULTS: Statistically significant differences in the genotype (P=0.007) and allele frequencies (P=0.0027) between schizophrenic patients with auditory hallucinations and controls were found in the single nucleotide polymorphism rs2396753. These P values changed to 0.07 and 0.0273, respectively, after Bonferroni sequential correction. The haplotype rs7803667T/rs10447760C/rs923875A/rs1358278A/rs2396753A (TCAAA) also showed a significant difference confirmed with a permutation test (P=0.009). CONCLUSIONS: These results suggested that the FOXP2 gene may confer vulnerability to schizophrenic patients with auditory hallucinations.

Adult↗